CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells

Mitotane is the reference drug for adrenocortical carcinoma (ACC) and the metabolic activation of the drug is considered as essential for its activity. The aim of this study was to assess the role of CYP11B1 on mitotane action and metabolism in H295R ACC cells to understand whether this enzyme may i...

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Detalles Bibliográficos
Autores principales: Germano, Antonina, Saba, Laura, De Francia, Silvia, Rapa, Ida, Perotti, Paola, Berruti, Alfredo, Volante, Marco, Terzolo, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937768/
https://www.ncbi.nlm.nih.gov/pubmed/29734384
http://dx.doi.org/10.1371/journal.pone.0196931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937768/
https://www.ncbi.nlm.nih.gov/pubmed/29734384
http://dx.doi.org/10.1371/journal.pone.0196931

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