RCP induces FAK phosphorylation and ovarian cancer cell invasion with inhibition by curcumin

Rab coupling protein (RCP) aggravates cancer cell metastasis and has been implicated in various cancer patient outcomes. Recently, we showed that RCP induces Slug expression and cancer cell invasion by stabilizing the β1 integrin protein. In the present study, we demonstrated that FAK is implicated...

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Autores principales: Choe, So Ra, Kim, Yu Na, Park, Chang Gyo, Cho, Kyung Hwa, Cho, Do Yeun, Lee, Hoi Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938006/
https://www.ncbi.nlm.nih.gov/pubmed/29700289
http://dx.doi.org/10.1038/s12276-018-0078-1
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author Choe, So Ra
Kim, Yu Na
Park, Chang Gyo
Cho, Kyung Hwa
Cho, Do Yeun
Lee, Hoi Young
author_facet Choe, So Ra
Kim, Yu Na
Park, Chang Gyo
Cho, Kyung Hwa
Cho, Do Yeun
Lee, Hoi Young
author_sort Choe, So Ra
collection PubMed
description Rab coupling protein (RCP) aggravates cancer cell metastasis and has been implicated in various cancer patient outcomes. Recently, we showed that RCP induces Slug expression and cancer cell invasion by stabilizing the β1 integrin protein. In the present study, we demonstrated that FAK is implicated in RCP-induced EGFR phosphorylation and ovarian cancer cell invasion with inhibition by curcumin. Ectopic expression of RCP induced FAK phosphorylation, which links β1 integrin with EGFR and participates in a positive regulation loop with EGFR. Interestingly, we observed for the first time that curcumin attenuates RCP-induced ovarian cancer cell invasion by blocking stabilization of β1 integrin and consequently inhibiting FAK and EGFR activation, providing potential biomarkers for ovarian cancer and therapeutic approaches for this deadly disease.
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spelling pubmed-59380062018-05-15 RCP induces FAK phosphorylation and ovarian cancer cell invasion with inhibition by curcumin Choe, So Ra Kim, Yu Na Park, Chang Gyo Cho, Kyung Hwa Cho, Do Yeun Lee, Hoi Young Exp Mol Med Article Rab coupling protein (RCP) aggravates cancer cell metastasis and has been implicated in various cancer patient outcomes. Recently, we showed that RCP induces Slug expression and cancer cell invasion by stabilizing the β1 integrin protein. In the present study, we demonstrated that FAK is implicated in RCP-induced EGFR phosphorylation and ovarian cancer cell invasion with inhibition by curcumin. Ectopic expression of RCP induced FAK phosphorylation, which links β1 integrin with EGFR and participates in a positive regulation loop with EGFR. Interestingly, we observed for the first time that curcumin attenuates RCP-induced ovarian cancer cell invasion by blocking stabilization of β1 integrin and consequently inhibiting FAK and EGFR activation, providing potential biomarkers for ovarian cancer and therapeutic approaches for this deadly disease. Nature Publishing Group UK 2018-04-27 /pmc/articles/PMC5938006/ /pubmed/29700289 http://dx.doi.org/10.1038/s12276-018-0078-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, and provide a link to the Creative Commons license. You do not have permission under this license to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, http://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Article
Choe, So Ra
Kim, Yu Na
Park, Chang Gyo
Cho, Kyung Hwa
Cho, Do Yeun
Lee, Hoi Young
RCP induces FAK phosphorylation and ovarian cancer cell invasion with inhibition by curcumin
title RCP induces FAK phosphorylation and ovarian cancer cell invasion with inhibition by curcumin
title_full RCP induces FAK phosphorylation and ovarian cancer cell invasion with inhibition by curcumin
title_fullStr RCP induces FAK phosphorylation and ovarian cancer cell invasion with inhibition by curcumin
title_full_unstemmed RCP induces FAK phosphorylation and ovarian cancer cell invasion with inhibition by curcumin
title_short RCP induces FAK phosphorylation and ovarian cancer cell invasion with inhibition by curcumin
title_sort rcp induces fak phosphorylation and ovarian cancer cell invasion with inhibition by curcumin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938006/
https://www.ncbi.nlm.nih.gov/pubmed/29700289
http://dx.doi.org/10.1038/s12276-018-0078-1
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