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S-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes

The myocardium in hypertensive heart exhibits decreased fatty acid utilization and contractile dysfunction, leading to cardiac failure. However, the causal relationship between metabolic remodeling and cardiomyocyte contractility remains unestablished. Transglutaminase 2 (TG2) has been known to prom...

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Detalles Bibliográficos
Autores principales: Jeong, Eui Man, Jin, Chun Zi, Jang, Ji Hyun, Zhao, Zai Hao, Jin, Chun Li, Lee, Jin Hang, Lee, Ki Baek, Kim, Sung Joon, Kim, In-Gyu, Zhang, Yin Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938015/
https://www.ncbi.nlm.nih.gov/pubmed/29622788
http://dx.doi.org/10.1038/s12276-017-0021-x

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