Wnt signal activation induces midbrain specification through direct binding of the beta-catenin/TCF4 complex to the EN1 promoter in human pluripotent stem cells

The canonical Wnt signal pathway plays a pivotal role in anteroposterior patterning and midbrain specification during early neurogenesis. Activating Wnt signal has been a strategy for differentiating human pluripotent stem cells (PSCs) into midbrain dopaminergic (DA) neurons; however, the underlying...

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Detalles Bibliográficos
Autores principales: Kim, Ji Young, Lee, Jae Souk, Hwang, Hyun Sub, Lee, Dongjin R., Park, Chul-Yong, Jung, Sung Jun, You, Young Rang, Kim, Dae-Sung, Kim, Dong-Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938028/
https://www.ncbi.nlm.nih.gov/pubmed/29650976
http://dx.doi.org/10.1038/s12276-018-0044-y

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