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Synaptic and circuit development of the primary sensory cortex
Animals, including humans, optimize their primary sensory cortex through the use of input signals, which allow them to adapt to the external environment and survive. The time window at the beginning of life in which external input signals are connected sensitively and strongly to neural circuit opti...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938038/ https://www.ncbi.nlm.nih.gov/pubmed/29628505 http://dx.doi.org/10.1038/s12276-018-0029-x |
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author | Choi, Se-Young |
author_facet | Choi, Se-Young |
author_sort | Choi, Se-Young |
collection | PubMed |
description | Animals, including humans, optimize their primary sensory cortex through the use of input signals, which allow them to adapt to the external environment and survive. The time window at the beginning of life in which external input signals are connected sensitively and strongly to neural circuit optimization is called the critical period. The critical period has attracted the attention of many neuroscientists due to the rapid activity-/experience-dependent circuit development that occurs, which is clearly differentiated from other developmental time periods and brain areas. This process involves various types of GABAergic inhibitory neurons, the extracellular matrix, neuromodulators, transcription factors, and neurodevelopmental factors. In this review, I discuss recent progress regarding the biological nature of the critical period that contribute to a better understanding of brain development. |
format | Online Article Text |
id | pubmed-5938038 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59380382018-05-15 Synaptic and circuit development of the primary sensory cortex Choi, Se-Young Exp Mol Med Review Article Animals, including humans, optimize their primary sensory cortex through the use of input signals, which allow them to adapt to the external environment and survive. The time window at the beginning of life in which external input signals are connected sensitively and strongly to neural circuit optimization is called the critical period. The critical period has attracted the attention of many neuroscientists due to the rapid activity-/experience-dependent circuit development that occurs, which is clearly differentiated from other developmental time periods and brain areas. This process involves various types of GABAergic inhibitory neurons, the extracellular matrix, neuromodulators, transcription factors, and neurodevelopmental factors. In this review, I discuss recent progress regarding the biological nature of the critical period that contribute to a better understanding of brain development. Nature Publishing Group UK 2018-04-09 /pmc/articles/PMC5938038/ /pubmed/29628505 http://dx.doi.org/10.1038/s12276-018-0029-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, and provide a link to the Creative Commons license. You do not have permission under this license to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, http://creativecommons.org/licenses/by-nc-nd/4.0/. |
spellingShingle | Review Article Choi, Se-Young Synaptic and circuit development of the primary sensory cortex |
title | Synaptic and circuit development of the primary sensory cortex |
title_full | Synaptic and circuit development of the primary sensory cortex |
title_fullStr | Synaptic and circuit development of the primary sensory cortex |
title_full_unstemmed | Synaptic and circuit development of the primary sensory cortex |
title_short | Synaptic and circuit development of the primary sensory cortex |
title_sort | synaptic and circuit development of the primary sensory cortex |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938038/ https://www.ncbi.nlm.nih.gov/pubmed/29628505 http://dx.doi.org/10.1038/s12276-018-0029-x |
work_keys_str_mv | AT choiseyoung synapticandcircuitdevelopmentoftheprimarysensorycortex |