Small-conductance Ca(2+)-activated K(+) channels: insights into their roles in cardiovascular disease

Life-threatening malignant arrhythmias in pathophysiological conditions can increase the mortality and morbidity of patients with cardiovascular diseases. Cardiac electrical activity depends on the coordinated propagation of excitatory stimuli and the generation of action potentials in cardiomyocyte...

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Autores principales: Gu, Mingxia, Zhu, Yanrong, Yin, Xiaorong, Zhang, Dai-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938042/
https://www.ncbi.nlm.nih.gov/pubmed/29651007
http://dx.doi.org/10.1038/s12276-018-0043-z
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author Gu, Mingxia
Zhu, Yanrong
Yin, Xiaorong
Zhang, Dai-Min
author_facet Gu, Mingxia
Zhu, Yanrong
Yin, Xiaorong
Zhang, Dai-Min
author_sort Gu, Mingxia
collection PubMed
description Life-threatening malignant arrhythmias in pathophysiological conditions can increase the mortality and morbidity of patients with cardiovascular diseases. Cardiac electrical activity depends on the coordinated propagation of excitatory stimuli and the generation of action potentials in cardiomyocytes. Action potential formation results from the opening and closing of ion channels. Recent studies have indicated that small-conductance calcium-activated potassium (SK) channels play a critical role in cardiac repolarization in pathophysiological but not normal physiological conditions. The aim of this review is to describe the role of SK channels in healthy and diseased hearts, to suggest cardiovascular pathophysiologic targets for intervention, and to discuss studies of agents that target SK channels for the treatment of cardiovascular diseases.
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spelling pubmed-59380422018-05-15 Small-conductance Ca(2+)-activated K(+) channels: insights into their roles in cardiovascular disease Gu, Mingxia Zhu, Yanrong Yin, Xiaorong Zhang, Dai-Min Exp Mol Med Review Article Life-threatening malignant arrhythmias in pathophysiological conditions can increase the mortality and morbidity of patients with cardiovascular diseases. Cardiac electrical activity depends on the coordinated propagation of excitatory stimuli and the generation of action potentials in cardiomyocytes. Action potential formation results from the opening and closing of ion channels. Recent studies have indicated that small-conductance calcium-activated potassium (SK) channels play a critical role in cardiac repolarization in pathophysiological but not normal physiological conditions. The aim of this review is to describe the role of SK channels in healthy and diseased hearts, to suggest cardiovascular pathophysiologic targets for intervention, and to discuss studies of agents that target SK channels for the treatment of cardiovascular diseases. Nature Publishing Group UK 2018-04-13 /pmc/articles/PMC5938042/ /pubmed/29651007 http://dx.doi.org/10.1038/s12276-018-0043-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, and provide a link to the Creative Commons license. You do not have permission under this license to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Review Article
Gu, Mingxia
Zhu, Yanrong
Yin, Xiaorong
Zhang, Dai-Min
Small-conductance Ca(2+)-activated K(+) channels: insights into their roles in cardiovascular disease
title Small-conductance Ca(2+)-activated K(+) channels: insights into their roles in cardiovascular disease
title_full Small-conductance Ca(2+)-activated K(+) channels: insights into their roles in cardiovascular disease
title_fullStr Small-conductance Ca(2+)-activated K(+) channels: insights into their roles in cardiovascular disease
title_full_unstemmed Small-conductance Ca(2+)-activated K(+) channels: insights into their roles in cardiovascular disease
title_short Small-conductance Ca(2+)-activated K(+) channels: insights into their roles in cardiovascular disease
title_sort small-conductance ca(2+)-activated k(+) channels: insights into their roles in cardiovascular disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938042/
https://www.ncbi.nlm.nih.gov/pubmed/29651007
http://dx.doi.org/10.1038/s12276-018-0043-z
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