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Comparative toxicity of dinophysistoxin-1 and okadaic acid in mice
The mouse bioassay for diarrhetic shellfish poisoning toxins has been used worldwide. In this study, dinophysistoxin-1 (DTX-1) and okadaic acid (OA) were compared for toxicity. The lethality rate increased and the median survival time decreased in a dose-dependent manner in both DTX-1 and OA. The me...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938189/ https://www.ncbi.nlm.nih.gov/pubmed/29491228 http://dx.doi.org/10.1292/jvms.17-0377 |
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author | SUZUKI, Hodaka OKADA, Yumiko |
author_facet | SUZUKI, Hodaka OKADA, Yumiko |
author_sort | SUZUKI, Hodaka |
collection | PubMed |
description | The mouse bioassay for diarrhetic shellfish poisoning toxins has been used worldwide. In this study, dinophysistoxin-1 (DTX-1) and okadaic acid (OA) were compared for toxicity. The lethality rate increased and the median survival time decreased in a dose-dependent manner in both DTX-1 and OA. The median lethal dose value was 150.4 µg/kg (95% confidence interval=130.1–171.2 µg/kg) for DTX-1 and 185.6 µg/kg (95% confidence interval=161.2–209.6 µg/kg) for OA. The toxicity equivalent factor 1:1 has been used for OA and DTX-1 in the EU and Japan. Thus, it may be considered that toxicity potential of DTX-1 has remained underestimated as compared to that of OA and DTX-1 might be more toxic than OA. |
format | Online Article Text |
id | pubmed-5938189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-59381892018-05-10 Comparative toxicity of dinophysistoxin-1 and okadaic acid in mice SUZUKI, Hodaka OKADA, Yumiko J Vet Med Sci Public Health The mouse bioassay for diarrhetic shellfish poisoning toxins has been used worldwide. In this study, dinophysistoxin-1 (DTX-1) and okadaic acid (OA) were compared for toxicity. The lethality rate increased and the median survival time decreased in a dose-dependent manner in both DTX-1 and OA. The median lethal dose value was 150.4 µg/kg (95% confidence interval=130.1–171.2 µg/kg) for DTX-1 and 185.6 µg/kg (95% confidence interval=161.2–209.6 µg/kg) for OA. The toxicity equivalent factor 1:1 has been used for OA and DTX-1 in the EU and Japan. Thus, it may be considered that toxicity potential of DTX-1 has remained underestimated as compared to that of OA and DTX-1 might be more toxic than OA. The Japanese Society of Veterinary Science 2018-03-01 2018-04 /pmc/articles/PMC5938189/ /pubmed/29491228 http://dx.doi.org/10.1292/jvms.17-0377 Text en ©2018 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Public Health SUZUKI, Hodaka OKADA, Yumiko Comparative toxicity of dinophysistoxin-1 and okadaic acid in mice |
title | Comparative toxicity of dinophysistoxin-1 and okadaic acid in
mice |
title_full | Comparative toxicity of dinophysistoxin-1 and okadaic acid in
mice |
title_fullStr | Comparative toxicity of dinophysistoxin-1 and okadaic acid in
mice |
title_full_unstemmed | Comparative toxicity of dinophysistoxin-1 and okadaic acid in
mice |
title_short | Comparative toxicity of dinophysistoxin-1 and okadaic acid in
mice |
title_sort | comparative toxicity of dinophysistoxin-1 and okadaic acid in
mice |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938189/ https://www.ncbi.nlm.nih.gov/pubmed/29491228 http://dx.doi.org/10.1292/jvms.17-0377 |
work_keys_str_mv | AT suzukihodaka comparativetoxicityofdinophysistoxin1andokadaicacidinmice AT okadayumiko comparativetoxicityofdinophysistoxin1andokadaicacidinmice |