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Dedifferentiated retroperitoneal liposarcoma spontaneously occurring in an aged SD rat

Liposarcoma is a rare neoplasm in rats and is characterized by the presence of lipoblasts containing multiple cytoplasmic vacuoles. We encountered a rare type of liposarcoma in a male SD (Crj:CD(SD)IGS) rat during a long-term study to gather background data. At necropsy at 105 weeks of age, there wa...

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Autores principales: Naito, Tomoharu, Saito, Tsuyoshi, Higuchi, Tamami, Inomata, Akira, Hayashi, Takuo, Shimada, Yasuhiro, Yamauchi-Ohguchi, Atsuko, Kenmochi, Sayaka, Kakinuma, Chihaya, Yao, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938215/
https://www.ncbi.nlm.nih.gov/pubmed/29750003
http://dx.doi.org/10.1293/tox.2017-0055
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author Naito, Tomoharu
Saito, Tsuyoshi
Higuchi, Tamami
Inomata, Akira
Hayashi, Takuo
Shimada, Yasuhiro
Yamauchi-Ohguchi, Atsuko
Kenmochi, Sayaka
Kakinuma, Chihaya
Yao, Takashi
author_facet Naito, Tomoharu
Saito, Tsuyoshi
Higuchi, Tamami
Inomata, Akira
Hayashi, Takuo
Shimada, Yasuhiro
Yamauchi-Ohguchi, Atsuko
Kenmochi, Sayaka
Kakinuma, Chihaya
Yao, Takashi
author_sort Naito, Tomoharu
collection PubMed
description Liposarcoma is a rare neoplasm in rats and is characterized by the presence of lipoblasts containing multiple cytoplasmic vacuoles. We encountered a rare type of liposarcoma in a male SD (Crj:CD(SD)IGS) rat during a long-term study to gather background data. At necropsy at 105 weeks of age, there was a large amount of fatty tissue covering the mesentery, pancreas, and retroperitoneum; a white nodule in the right kidney; and paleness of the liver. Microscopically, the tumor had a well-differentiated component and dedifferentiated high-grade component. Immunohistochemical and electron microscopic examinations revealed that the pleomorphic tumor cells retained the characteristics of lipoblasts. Distant or disseminated metastasis was also confirmed in various organs. A liposarcoma with these histological features is extremely rare in rats, and this is the first report of a highly metastatic dedifferentiated type of liposarcoma originating from the abdominal fat tissue in a rat.
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spelling pubmed-59382152018-05-10 Dedifferentiated retroperitoneal liposarcoma spontaneously occurring in an aged SD rat Naito, Tomoharu Saito, Tsuyoshi Higuchi, Tamami Inomata, Akira Hayashi, Takuo Shimada, Yasuhiro Yamauchi-Ohguchi, Atsuko Kenmochi, Sayaka Kakinuma, Chihaya Yao, Takashi J Toxicol Pathol Case Report Liposarcoma is a rare neoplasm in rats and is characterized by the presence of lipoblasts containing multiple cytoplasmic vacuoles. We encountered a rare type of liposarcoma in a male SD (Crj:CD(SD)IGS) rat during a long-term study to gather background data. At necropsy at 105 weeks of age, there was a large amount of fatty tissue covering the mesentery, pancreas, and retroperitoneum; a white nodule in the right kidney; and paleness of the liver. Microscopically, the tumor had a well-differentiated component and dedifferentiated high-grade component. Immunohistochemical and electron microscopic examinations revealed that the pleomorphic tumor cells retained the characteristics of lipoblasts. Distant or disseminated metastasis was also confirmed in various organs. A liposarcoma with these histological features is extremely rare in rats, and this is the first report of a highly metastatic dedifferentiated type of liposarcoma originating from the abdominal fat tissue in a rat. Japanese Society of Toxicologic Pathology 2018-01-06 2018-04 /pmc/articles/PMC5938215/ /pubmed/29750003 http://dx.doi.org/10.1293/tox.2017-0055 Text en ©2018 The Japanese Society of Toxicologic Pathology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Naito, Tomoharu
Saito, Tsuyoshi
Higuchi, Tamami
Inomata, Akira
Hayashi, Takuo
Shimada, Yasuhiro
Yamauchi-Ohguchi, Atsuko
Kenmochi, Sayaka
Kakinuma, Chihaya
Yao, Takashi
Dedifferentiated retroperitoneal liposarcoma spontaneously occurring in an aged SD rat
title Dedifferentiated retroperitoneal liposarcoma spontaneously occurring in an aged SD rat
title_full Dedifferentiated retroperitoneal liposarcoma spontaneously occurring in an aged SD rat
title_fullStr Dedifferentiated retroperitoneal liposarcoma spontaneously occurring in an aged SD rat
title_full_unstemmed Dedifferentiated retroperitoneal liposarcoma spontaneously occurring in an aged SD rat
title_short Dedifferentiated retroperitoneal liposarcoma spontaneously occurring in an aged SD rat
title_sort dedifferentiated retroperitoneal liposarcoma spontaneously occurring in an aged sd rat
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938215/
https://www.ncbi.nlm.nih.gov/pubmed/29750003
http://dx.doi.org/10.1293/tox.2017-0055
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