Cargando…

Persistence of vertebral growth plate cartilage in aged cynomolgus monkeys

Growth plates at each end of vertebral bodies play a pivotal role in longitudinal spinal growth. Epiphyseal closures are formed in adult humans. Although monkeys are frequently employed in bone and disc research, the age of epiphyseal closure has not been well documented. In this study, histological...

Descripción completa

Detalles Bibliográficos
Autores principales: Iwata, Munetaka, Yamamoto, Wataru, Shimomoto, Takasumi, Okada, Yuki, Oosawa, Satomi, Miura, Daishiro, Hara, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938217/
https://www.ncbi.nlm.nih.gov/pubmed/29750005
http://dx.doi.org/10.1293/tox.2017-0041
_version_ 1783320742773915648
author Iwata, Munetaka
Yamamoto, Wataru
Shimomoto, Takasumi
Okada, Yuki
Oosawa, Satomi
Miura, Daishiro
Hara, Yasushi
author_facet Iwata, Munetaka
Yamamoto, Wataru
Shimomoto, Takasumi
Okada, Yuki
Oosawa, Satomi
Miura, Daishiro
Hara, Yasushi
author_sort Iwata, Munetaka
collection PubMed
description Growth plates at each end of vertebral bodies play a pivotal role in longitudinal spinal growth. Epiphyseal closures are formed in adult humans. Although monkeys are frequently employed in bone and disc research, the age of epiphyseal closure has not been well documented. In this study, histological analyses of lumbar vertebral end plates and the surrounding tissue were performed in 11 normal cynomolgus monkeys aged approximately 9 to 15 years, and unclosed growth plate cartilage was detected in all the end plates. The data from this study constitute the first documentation of persistent vertebral growth plate cartilage in cynomolgus monkeys. The persistence of growth plate cartilage in cynomolgus monkeys approximately 15 years of age or younger, which differs from the complete epiphyseal closure exhibited in adult humans, may affect the biomechanical behavior of the spine. This is an important factor to consider in extrapolating the results of spine and intervertebral disc research using cynomolgus monkeys to adult humans.
format Online
Article
Text
id pubmed-5938217
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Japanese Society of Toxicologic Pathology
record_format MEDLINE/PubMed
spelling pubmed-59382172018-05-10 Persistence of vertebral growth plate cartilage in aged cynomolgus monkeys Iwata, Munetaka Yamamoto, Wataru Shimomoto, Takasumi Okada, Yuki Oosawa, Satomi Miura, Daishiro Hara, Yasushi J Toxicol Pathol Short Communication Growth plates at each end of vertebral bodies play a pivotal role in longitudinal spinal growth. Epiphyseal closures are formed in adult humans. Although monkeys are frequently employed in bone and disc research, the age of epiphyseal closure has not been well documented. In this study, histological analyses of lumbar vertebral end plates and the surrounding tissue were performed in 11 normal cynomolgus monkeys aged approximately 9 to 15 years, and unclosed growth plate cartilage was detected in all the end plates. The data from this study constitute the first documentation of persistent vertebral growth plate cartilage in cynomolgus monkeys. The persistence of growth plate cartilage in cynomolgus monkeys approximately 15 years of age or younger, which differs from the complete epiphyseal closure exhibited in adult humans, may affect the biomechanical behavior of the spine. This is an important factor to consider in extrapolating the results of spine and intervertebral disc research using cynomolgus monkeys to adult humans. Japanese Society of Toxicologic Pathology 2018-02-10 2018-04 /pmc/articles/PMC5938217/ /pubmed/29750005 http://dx.doi.org/10.1293/tox.2017-0041 Text en ©2018 The Japanese Society of Toxicologic Pathology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Iwata, Munetaka
Yamamoto, Wataru
Shimomoto, Takasumi
Okada, Yuki
Oosawa, Satomi
Miura, Daishiro
Hara, Yasushi
Persistence of vertebral growth plate cartilage in aged cynomolgus monkeys
title Persistence of vertebral growth plate cartilage in aged cynomolgus monkeys
title_full Persistence of vertebral growth plate cartilage in aged cynomolgus monkeys
title_fullStr Persistence of vertebral growth plate cartilage in aged cynomolgus monkeys
title_full_unstemmed Persistence of vertebral growth plate cartilage in aged cynomolgus monkeys
title_short Persistence of vertebral growth plate cartilage in aged cynomolgus monkeys
title_sort persistence of vertebral growth plate cartilage in aged cynomolgus monkeys
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938217/
https://www.ncbi.nlm.nih.gov/pubmed/29750005
http://dx.doi.org/10.1293/tox.2017-0041
work_keys_str_mv AT iwatamunetaka persistenceofvertebralgrowthplatecartilageinagedcynomolgusmonkeys
AT yamamotowataru persistenceofvertebralgrowthplatecartilageinagedcynomolgusmonkeys
AT shimomototakasumi persistenceofvertebralgrowthplatecartilageinagedcynomolgusmonkeys
AT okadayuki persistenceofvertebralgrowthplatecartilageinagedcynomolgusmonkeys
AT oosawasatomi persistenceofvertebralgrowthplatecartilageinagedcynomolgusmonkeys
AT miuradaishiro persistenceofvertebralgrowthplatecartilageinagedcynomolgusmonkeys
AT harayasushi persistenceofvertebralgrowthplatecartilageinagedcynomolgusmonkeys