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Grainyhead-like 2 (GRHL2) knockout abolishes oral cancer development through reciprocal regulation of the MAP kinase and TGF-β signaling pathways

Grainyhead-Like 2 (GRHL2) is an epithelial-specific transcription factor that regulates epithelial morphogenesis and differentiation. Prior studies suggested inverse regulation between GRHL2 and TGF-β in epithelial plasticity and potential carcinogenesis. Here, we report the role of GRHL2 in oral ca...

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Detalles Bibliográficos
Autores principales:	Chen, Wei, Kang, Kyung L., Alshaikh, Abdullah, Varma, Saaket, Lin, Yi-Ling, Shin, Ki-Hyuk, Kim, Reuben, Wang, Cun-Yu, Park, No-Hee, Walentin, Katharina, Schmidt-Ott, Kai M., Kang, Mo K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938237/ https://www.ncbi.nlm.nih.gov/pubmed/29735981 http://dx.doi.org/10.1038/s41389-018-0047-5

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