Sequence determinants of specific pattern-recognition of bacterial ligands by the NAIP–NLRC4 inflammasome

The NLR apoptosis inhibitory proteins (NAIPs) function as specific cytosolic receptors for bacterial ligands to form the NAIP–NLRC4 inflammasome for anti-bacterial defenses. In mice, NAIP5/6 and NAIP2 recognize bacteria flagellin and the rod protein of the type III secretion system (T3SS), respectiv...

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Detalles Bibliográficos
Autores principales: Yang, Jingyi, Zhao, Yue, Li, Peng, Yang, Yi, Zhang, Ejuan, Zhong, Maohua, Li, Yaoming, Zhou, Dihan, Cao, Yuan, Lu, Mengji, Shao, Feng, Yan, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938239/
https://www.ncbi.nlm.nih.gov/pubmed/29760946
http://dx.doi.org/10.1038/s41421-018-0018-1

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