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Dual-nozzle microfluidic droplet generator
The droplet-generating microfluidics has become an important technique for a variety of applications ranging from single cell analysis to nanoparticle synthesis. Although there are a large number of methods for generating and experimenting with droplets on microfluidic devices, the dispensing of dro...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938299/ https://www.ncbi.nlm.nih.gov/pubmed/29755924 http://dx.doi.org/10.1186/s40580-018-0145-2 |
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author | Choi, Ji Wook Lee, Jong Min Kim, Tae Hyun Ha, Jang Ho Ahrberg, Christian D. Chung, Bong Geun |
author_facet | Choi, Ji Wook Lee, Jong Min Kim, Tae Hyun Ha, Jang Ho Ahrberg, Christian D. Chung, Bong Geun |
author_sort | Choi, Ji Wook |
collection | PubMed |
description | The droplet-generating microfluidics has become an important technique for a variety of applications ranging from single cell analysis to nanoparticle synthesis. Although there are a large number of methods for generating and experimenting with droplets on microfluidic devices, the dispensing of droplets from these microfluidic devices is a challenge due to aggregation and merging of droplets at the interface of microfluidic devices. Here, we present a microfluidic dual-nozzle device for the generation and dispensing of uniform-sized droplets. The first nozzle of the microfluidic device is used for the generation of the droplets, while the second nozzle can accelerate the droplets and increase the spacing between them, allowing for facile dispensing of droplets. Computational fluid dynamic simulations were conducted to optimize the design parameters of the microfluidic device. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40580-018-0145-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5938299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-59382992018-05-11 Dual-nozzle microfluidic droplet generator Choi, Ji Wook Lee, Jong Min Kim, Tae Hyun Ha, Jang Ho Ahrberg, Christian D. Chung, Bong Geun Nano Converg Research The droplet-generating microfluidics has become an important technique for a variety of applications ranging from single cell analysis to nanoparticle synthesis. Although there are a large number of methods for generating and experimenting with droplets on microfluidic devices, the dispensing of droplets from these microfluidic devices is a challenge due to aggregation and merging of droplets at the interface of microfluidic devices. Here, we present a microfluidic dual-nozzle device for the generation and dispensing of uniform-sized droplets. The first nozzle of the microfluidic device is used for the generation of the droplets, while the second nozzle can accelerate the droplets and increase the spacing between them, allowing for facile dispensing of droplets. Computational fluid dynamic simulations were conducted to optimize the design parameters of the microfluidic device. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40580-018-0145-2) contains supplementary material, which is available to authorized users. Springer Singapore 2018-05-08 /pmc/articles/PMC5938299/ /pubmed/29755924 http://dx.doi.org/10.1186/s40580-018-0145-2 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Research Choi, Ji Wook Lee, Jong Min Kim, Tae Hyun Ha, Jang Ho Ahrberg, Christian D. Chung, Bong Geun Dual-nozzle microfluidic droplet generator |
title | Dual-nozzle microfluidic droplet generator |
title_full | Dual-nozzle microfluidic droplet generator |
title_fullStr | Dual-nozzle microfluidic droplet generator |
title_full_unstemmed | Dual-nozzle microfluidic droplet generator |
title_short | Dual-nozzle microfluidic droplet generator |
title_sort | dual-nozzle microfluidic droplet generator |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938299/ https://www.ncbi.nlm.nih.gov/pubmed/29755924 http://dx.doi.org/10.1186/s40580-018-0145-2 |
work_keys_str_mv | AT choijiwook dualnozzlemicrofluidicdropletgenerator AT leejongmin dualnozzlemicrofluidicdropletgenerator AT kimtaehyun dualnozzlemicrofluidicdropletgenerator AT hajangho dualnozzlemicrofluidicdropletgenerator AT ahrbergchristiand dualnozzlemicrofluidicdropletgenerator AT chungbonggeun dualnozzlemicrofluidicdropletgenerator |