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Dual-nozzle microfluidic droplet generator

The droplet-generating microfluidics has become an important technique for a variety of applications ranging from single cell analysis to nanoparticle synthesis. Although there are a large number of methods for generating and experimenting with droplets on microfluidic devices, the dispensing of dro...

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Autores principales: Choi, Ji Wook, Lee, Jong Min, Kim, Tae Hyun, Ha, Jang Ho, Ahrberg, Christian D., Chung, Bong Geun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938299/
https://www.ncbi.nlm.nih.gov/pubmed/29755924
http://dx.doi.org/10.1186/s40580-018-0145-2
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author Choi, Ji Wook
Lee, Jong Min
Kim, Tae Hyun
Ha, Jang Ho
Ahrberg, Christian D.
Chung, Bong Geun
author_facet Choi, Ji Wook
Lee, Jong Min
Kim, Tae Hyun
Ha, Jang Ho
Ahrberg, Christian D.
Chung, Bong Geun
author_sort Choi, Ji Wook
collection PubMed
description The droplet-generating microfluidics has become an important technique for a variety of applications ranging from single cell analysis to nanoparticle synthesis. Although there are a large number of methods for generating and experimenting with droplets on microfluidic devices, the dispensing of droplets from these microfluidic devices is a challenge due to aggregation and merging of droplets at the interface of microfluidic devices. Here, we present a microfluidic dual-nozzle device for the generation and dispensing of uniform-sized droplets. The first nozzle of the microfluidic device is used for the generation of the droplets, while the second nozzle can accelerate the droplets and increase the spacing between them, allowing for facile dispensing of droplets. Computational fluid dynamic simulations were conducted to optimize the design parameters of the microfluidic device. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40580-018-0145-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-59382992018-05-11 Dual-nozzle microfluidic droplet generator Choi, Ji Wook Lee, Jong Min Kim, Tae Hyun Ha, Jang Ho Ahrberg, Christian D. Chung, Bong Geun Nano Converg Research The droplet-generating microfluidics has become an important technique for a variety of applications ranging from single cell analysis to nanoparticle synthesis. Although there are a large number of methods for generating and experimenting with droplets on microfluidic devices, the dispensing of droplets from these microfluidic devices is a challenge due to aggregation and merging of droplets at the interface of microfluidic devices. Here, we present a microfluidic dual-nozzle device for the generation and dispensing of uniform-sized droplets. The first nozzle of the microfluidic device is used for the generation of the droplets, while the second nozzle can accelerate the droplets and increase the spacing between them, allowing for facile dispensing of droplets. Computational fluid dynamic simulations were conducted to optimize the design parameters of the microfluidic device. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40580-018-0145-2) contains supplementary material, which is available to authorized users. Springer Singapore 2018-05-08 /pmc/articles/PMC5938299/ /pubmed/29755924 http://dx.doi.org/10.1186/s40580-018-0145-2 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Choi, Ji Wook
Lee, Jong Min
Kim, Tae Hyun
Ha, Jang Ho
Ahrberg, Christian D.
Chung, Bong Geun
Dual-nozzle microfluidic droplet generator
title Dual-nozzle microfluidic droplet generator
title_full Dual-nozzle microfluidic droplet generator
title_fullStr Dual-nozzle microfluidic droplet generator
title_full_unstemmed Dual-nozzle microfluidic droplet generator
title_short Dual-nozzle microfluidic droplet generator
title_sort dual-nozzle microfluidic droplet generator
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938299/
https://www.ncbi.nlm.nih.gov/pubmed/29755924
http://dx.doi.org/10.1186/s40580-018-0145-2
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