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Utility of a Novel Three-Dimensional and Dynamic (3DD) Cell Culture System for PK/PD Studies: Evaluation of a Triple Combination Therapy at Overcoming Anti-HER2 Treatment Resistance in Breast Cancer

Background: Emergence of Human epidermal growth factor receptor 2 (HER2) therapy resistance in HER2-positive (HER2+) breast cancer (BC) poses a major clinical challenge. Mechanisms of resistance include the over-activation of the PI3K/mTOR and Src pathways. This work aims to investigate a novel comb...

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Detalles Bibliográficos
Autores principales:	Ande, Anusha, Vaidya, Tanaya R., Tran, Bao N., Vicchiarelli, Michael, Brown, Ashley N., Ait-Oudhia, Sihem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938355/ https://www.ncbi.nlm.nih.gov/pubmed/29765318 http://dx.doi.org/10.3389/fphar.2018.00403

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