Cargando…

Evodiamine, a Novel NOTCH3 Methylation Stimulator, Significantly Suppresses Lung Carcinogenesis in Vitro and in Vivo

Lung cancer is a leading cause of cancer-related deaths worldwide. NOTCH3 signaling is mainly expressed in non-small cell lung carcinoma (NSCLC), and has been proposed as a therapeutic target of NSCLC. While, few agents for preventing or treating NSCLC via targeting NOTCH3 signaling are used in mode...

Descripción completa

Detalles Bibliográficos
Autores principales:	Su, Tao, Yang, Xia, Deng, Jian-Hua, Huang, Qiu-Ju, Huang, Su-Chao, Zhang, Yan-Min, Zheng, Hong-Ming, Wang, Ying, Lu, Lin-Lin, Liu, Zhong-Qiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938359/ https://www.ncbi.nlm.nih.gov/pubmed/29765324 http://dx.doi.org/10.3389/fphar.2018.00434

Ejemplares similares

The Protective Effect of Evodiamine in Osteoarthritis: An In Vitro and In Vivo Study in Mice Model
por: Xian, Shuyuan, et al.
Publicado: (2022)

Apigenin Inhibits IL-6 Transcription and Suppresses Esophageal Carcinogenesis
por: Qiu, Jian-Ge, et al.
Publicado: (2019)

Evodiamine Eliminates Colon Cancer Stem Cells via Suppressing Notch and Wnt Signaling
por: Kim, Hyejin, et al.
Publicado: (2019)

Evaluation of the Cardiotoxicity of Evodiamine In Vitro and In Vivo
por: Yang, Weifeng, et al.
Publicado: (2017)

Differences in tissue distribution ability of evodiamine and dehydroevodiamine are due to the dihedral angle of the molecule stereo-structure
por: Luo, Jie, et al.
Publicado: (2023)

Evodiamine Attenuates Experimental Colitis Injury Via Activating Autophagy and Inhibiting NLRP3 Inflammasome Assembly
por: Ding, Wenwen, et al.
Publicado: (2020)

Characterization of the in Vitro Metabolic Profile of Evodiamine in Human Liver Microsomes and Hepatocytes by UHPLC-Q Exactive Mass Spectrometer
por: Zhang, Zhaowei, et al.
Publicado: (2018)

Evodiamine Augments NLRP3 Inflammasome Activation and Anti-bacterial Responses Through Inducing α-Tubulin Acetylation
por: Li, Chen-Guang, et al.
Publicado: (2019)

Enhanced transdermal delivery of evodiamine and rutaecarpine using microemulsion
por: Zhang, Yong-Tai, et al.
Publicado: (2011)

In vitro cellular uptake of evodiamine and rutaecarpine using a microemulsion
por: Zhang, Yong-Tai, et al.
Publicado: (2012)

Amelioration of AOM/DSS-Induced Murine Colitis-Associated Cancer by Evodiamine Intervention is Primarily Associated with Gut Microbiota-Metabolism-Inflammatory Signaling Axis
por: Wang, Mengxia, et al.
Publicado: (2021)

Evodiamine Exerts an Anti-Hepatocellular Carcinoma Activity through a WWOX-Dependent Pathway
por: Hu, Che-Yuan, et al.
Publicado: (2017)

Preventive Effects of Evodiamine on Dexamethasone-Induced Osteoporosis in Zebrafish
por: Yin, Heng, et al.
Publicado: (2019)

A Critical YAP in Malignancy of HCC Is Regulated by Evodiamine
por: Yun, Un-Jung, et al.
Publicado: (2022)

Metabolomics profiling of AKT/c-Met-induced hepatocellular carcinogenesis and the inhibitory effect of Cucurbitacin B in mice
por: Ji, Xiangyu, et al.
Publicado: (2022)

Compatibility of Fuzi and Ginseng Significantly Increase the Exposure of Aconitines
por: Chen, Ze-Yan, et al.
Publicado: (2022)

Effect of evodiamine and berberine on miR-429 as an oncogene in human colorectal cancer
por: Liu, Hong, et al.
Publicado: (2016)

Evodiamine Exhibits Anti-Bladder Cancer Activity by Suppression of Glutathione Peroxidase 4 and Induction of Ferroptosis
por: Hu, Che-Yuan, et al.
Publicado: (2023)

Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-Activated Protein Kinase Alpha In vivo and In vitro
por: Lim, Hara, et al.
Publicado: (2016)

Improved absorption and in vivo kinetic characteristics of nanoemulsions containing evodiamine–phospholipid nanocomplex
por: Hu, Jiangbo, et al.
Publicado: (2014)

Pioglitazone, a PPAR-γ Activator, Stimulates BK(Ca) but Suppresses IK(M) in Hippocampal Neurons
por: Chen, Tsang-Shan, et al.
Publicado: (2018)

Actein Inhibits the Proliferation and Adhesion of Human Breast Cancer Cells and Suppresses Migration in vivo
por: Wu, Xiao-Xiao, et al.
Publicado: (2018)

Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma
por: Wang, Rong, et al.
Publicado: (2018)

Methyl Gallate Suppresses the Migration, Invasion, and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells via the AMPK/NF-κB Signaling Pathway in vitro and in vivo
por: Liang, Huaguo, et al.
Publicado: (2022)

Midkine-Notch2 Pathway Mediates Excessive Proliferation of Airway Smooth Muscle Cells in Chronic Obstructive Lung Disease
por: Deng, Tang, et al.
Publicado: (2022)

A small molecule inhibitor of Notch1 modulates stemness and suppresses breast cancer cell growth
por: Saran, Uttara, et al.
Publicado: (2023)

KRIBB11: A Promising Drug that Promotes Microglial Process Elongation and Suppresses Neuroinflammation
por: Su, Jianbin, et al.
Publicado: (2022)

Corrigendum: A small molecule inhibitor of Notch1 modulates stemness and suppresses breast cancer cell growth
por: Saran, Uttara, et al.
Publicado: (2023)

Evodiamine suppresses the progression of non-small cell lung carcinoma via endoplasmic reticulum stress-mediated apoptosis pathway in vivo and in vitro
por: Li, Yuting, et al.
Publicado: (2022)

Preparation of Evodiamine Solid Dispersions and Its Pharmacokinetics
por: Xu, H., et al.
Publicado: (2011)

Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives
por: Hu, Xu, et al.
Publicado: (2018)

Pharmacological Actions of Multi-Target-Directed Evodiamine
por: Yu, Hui, et al.
Publicado: (2013)

Suppression of Esophageal Cancer Stem-like Cells by SNX-2112 Is Enhanced by STAT3 Silencing
por: Xu, Dan-dan, et al.
Publicado: (2020)

Protection against ulcerative colitis and colorectal cancer by evodiamine via anti-inflammatory effects
por: Zhang, Yongfeng, et al.
Publicado: (2022)

Xiaoai Jiedu Recipe suppresses hepatocellular carcinogenesis through the miR‐200b-3p /Notch1 axis
por: Qiu, Wenli, et al.
Publicado: (2020)

Corydalis Saxicola Bunting Total Alkaloids Attenuate Walker 256-Induced Bone Pain and Osteoclastogenesis by Suppressing RANKL-Induced NF-κB and c-Fos/NFATc1 Pathways in Rats
por: Ju, Linjie, et al.
Publicado: (2021)

Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway
por: Zhang, Zhen-Biao, et al.
Publicado: (2018)

Nuclear Magnetic Resonance-Based Metabolomics Approach to Evaluate the Prevention Effect of Camellia nitidissima Chi on Colitis-Associated Carcinogenesis
por: Li, Ming-Hui, et al.
Publicado: (2017)

18β-Glycyrrhetinic Acid Inhibits Osteoclastogenesis In Vivo and In Vitro by Blocking RANKL-Mediated RANK–TRAF6 Interactions and NF-κB and MAPK Signaling Pathways
por: Chen, Xiao, et al.
Publicado: (2018)

Role of MLH1 methylation in esophageal cancer carcinogenesis and its clinical significance
por: Li, Jinyun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8mlsnscmvi5tnluu5s4ps79dna