Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis?

The emergence of strains of Mycobacterium tuberculosis resistant to isoniazid (INH) has underscored the need for the development of new anti-tuberculosis agents. INH is activated by the mycobacterial katG-encoded catalase-peroxidase, forming an acylpyridine fragment that is covalently attached to th...

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Detalles Bibliográficos
Autores principales: Abbadi, Bruno L., Rodrigues-Junior, Valnês da Silva, Dadda, Adilio da Silva, Pissinate, Kenia, Villela, Anne D., Campos, Maria M., Lopes, Luiz G. de França, Bizarro, Cristiano V., Machado, Pablo, Sousa, Eduardo H. S., Basso, Luiz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938375/
https://www.ncbi.nlm.nih.gov/pubmed/29765372
http://dx.doi.org/10.3389/fmicb.2018.00880

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