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Beneficial Effects of Elderly Tailored Mediterranean Diet on the Proteasomal Proteolysis
Aging is a multifactorial process characterized by the accumulation of proteins undergoing oxidative modifications, either due to enhanced levels of oxidative stress or due to their decreased clearance; both facts are related to the establishment of chronic inflammatory processes. These processes ar...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938393/ https://www.ncbi.nlm.nih.gov/pubmed/29765333 http://dx.doi.org/10.3389/fphys.2018.00457 |
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author | Athanasopoulou, Sophia Chondrogianni, Niki Santoro, Aurelia Asimaki, Konstantina Delitsikou, Vasiliki Voutetakis, Konstantinos Fabbri, Cristina Pietruszka, Barbara Kaluza, Joanna Franceschi, Claudio Gonos, Efstathios S. |
author_facet | Athanasopoulou, Sophia Chondrogianni, Niki Santoro, Aurelia Asimaki, Konstantina Delitsikou, Vasiliki Voutetakis, Konstantinos Fabbri, Cristina Pietruszka, Barbara Kaluza, Joanna Franceschi, Claudio Gonos, Efstathios S. |
author_sort | Athanasopoulou, Sophia |
collection | PubMed |
description | Aging is a multifactorial process characterized by the accumulation of proteins undergoing oxidative modifications, either due to enhanced levels of oxidative stress or due to their decreased clearance; both facts are related to the establishment of chronic inflammatory processes. These processes are directly associated with functional and structural modifications of a key cellular component, namely the proteasome. In this study, levels of oxidized proteins, along with proteasome and immunoproteasome composition and activity on a selected group of 120 elderly volunteers were analyzed before and after the administration of a specific dietary protocol, based on an elderly tailored Mediterranean diet (the “NU-AGE diet”). A significant negative correlation between levels of oxidized/carbonylated proteins and proteasome function was confirmed, both before and after intervention. Furthermore, it was demonstrated that subgroups of non-frail subjects and women receive a greater benefit after the intervention, concerning specifically the proteasome content and activity. These data highlight the putative beneficial effects of Mediterranean diet on the major cellular proteolytic mechanism, the proteasome, in elderly people. |
format | Online Article Text |
id | pubmed-5938393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59383932018-05-14 Beneficial Effects of Elderly Tailored Mediterranean Diet on the Proteasomal Proteolysis Athanasopoulou, Sophia Chondrogianni, Niki Santoro, Aurelia Asimaki, Konstantina Delitsikou, Vasiliki Voutetakis, Konstantinos Fabbri, Cristina Pietruszka, Barbara Kaluza, Joanna Franceschi, Claudio Gonos, Efstathios S. Front Physiol Physiology Aging is a multifactorial process characterized by the accumulation of proteins undergoing oxidative modifications, either due to enhanced levels of oxidative stress or due to their decreased clearance; both facts are related to the establishment of chronic inflammatory processes. These processes are directly associated with functional and structural modifications of a key cellular component, namely the proteasome. In this study, levels of oxidized proteins, along with proteasome and immunoproteasome composition and activity on a selected group of 120 elderly volunteers were analyzed before and after the administration of a specific dietary protocol, based on an elderly tailored Mediterranean diet (the “NU-AGE diet”). A significant negative correlation between levels of oxidized/carbonylated proteins and proteasome function was confirmed, both before and after intervention. Furthermore, it was demonstrated that subgroups of non-frail subjects and women receive a greater benefit after the intervention, concerning specifically the proteasome content and activity. These data highlight the putative beneficial effects of Mediterranean diet on the major cellular proteolytic mechanism, the proteasome, in elderly people. Frontiers Media S.A. 2018-05-01 /pmc/articles/PMC5938393/ /pubmed/29765333 http://dx.doi.org/10.3389/fphys.2018.00457 Text en Copyright © 2018 Athanasopoulou, Chondrogianni, Santoro, Asimaki, Delitsikou, Voutetakis, Fabbri, Pietruszka, Kaluza, Franceschi and Gonos. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Athanasopoulou, Sophia Chondrogianni, Niki Santoro, Aurelia Asimaki, Konstantina Delitsikou, Vasiliki Voutetakis, Konstantinos Fabbri, Cristina Pietruszka, Barbara Kaluza, Joanna Franceschi, Claudio Gonos, Efstathios S. Beneficial Effects of Elderly Tailored Mediterranean Diet on the Proteasomal Proteolysis |
title | Beneficial Effects of Elderly Tailored Mediterranean Diet on the Proteasomal Proteolysis |
title_full | Beneficial Effects of Elderly Tailored Mediterranean Diet on the Proteasomal Proteolysis |
title_fullStr | Beneficial Effects of Elderly Tailored Mediterranean Diet on the Proteasomal Proteolysis |
title_full_unstemmed | Beneficial Effects of Elderly Tailored Mediterranean Diet on the Proteasomal Proteolysis |
title_short | Beneficial Effects of Elderly Tailored Mediterranean Diet on the Proteasomal Proteolysis |
title_sort | beneficial effects of elderly tailored mediterranean diet on the proteasomal proteolysis |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938393/ https://www.ncbi.nlm.nih.gov/pubmed/29765333 http://dx.doi.org/10.3389/fphys.2018.00457 |
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