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Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function

NAD(P)H-hydrate epimerase (EC 5.1.99.6) is known to help repair NAD(P)H hydrates (NAD(P)HX), which are damage products existing as R and S epimers. The S epimer is reconverted to NAD(P)H by a dehydratase; the epimerase facilitates epimer interconversion. Epimerase deficiency in humans causes a letha...

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Detalles Bibliográficos
Autores principales:	Niehaus, Thomas D., Elbadawi-Sidhu, Mona, Huang, Lili, Prunetti, Laurence, Gregory, Jesse F., de Crécy-Lagard, Valérie, Fiehn, Oliver, Hanson, Andrew D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938422/ https://www.ncbi.nlm.nih.gov/pubmed/29654173 http://dx.doi.org/10.1042/BSR20180223

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