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Interferon regulatory factor 1 inactivation in human cancer

Interferon regulatory factors (IRFs) are a group of closely related proteins collectively referred to as the IRF family. Members of this family were originally recognized for their roles in inflammatory responses; however, recent research has suggested that they are also involved in tumor biology. T...

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Detalles Bibliográficos
Autores principales: Alsamman, Khaldoon, El-Masry, Omar S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938431/
https://www.ncbi.nlm.nih.gov/pubmed/29599126
http://dx.doi.org/10.1042/BSR20171672
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author Alsamman, Khaldoon
El-Masry, Omar S.
author_facet Alsamman, Khaldoon
El-Masry, Omar S.
author_sort Alsamman, Khaldoon
collection PubMed
description Interferon regulatory factors (IRFs) are a group of closely related proteins collectively referred to as the IRF family. Members of this family were originally recognized for their roles in inflammatory responses; however, recent research has suggested that they are also involved in tumor biology. This review focusses on current knowledge of the roles of IRF-1 and IRF-2 in human cancer, with particular attention paid to the impact of IRF-1 inactivation. The different mechanisms underlying IRF-1 inactivation and their implications for human cancers and the potential importance of IRF-1 in immunotherapy are also summarized.
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spelling pubmed-59384312018-05-15 Interferon regulatory factor 1 inactivation in human cancer Alsamman, Khaldoon El-Masry, Omar S. Biosci Rep Review Articles Interferon regulatory factors (IRFs) are a group of closely related proteins collectively referred to as the IRF family. Members of this family were originally recognized for their roles in inflammatory responses; however, recent research has suggested that they are also involved in tumor biology. This review focusses on current knowledge of the roles of IRF-1 and IRF-2 in human cancer, with particular attention paid to the impact of IRF-1 inactivation. The different mechanisms underlying IRF-1 inactivation and their implications for human cancers and the potential importance of IRF-1 in immunotherapy are also summarized. Portland Press Ltd. 2018-05-08 /pmc/articles/PMC5938431/ /pubmed/29599126 http://dx.doi.org/10.1042/BSR20171672 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Alsamman, Khaldoon
El-Masry, Omar S.
Interferon regulatory factor 1 inactivation in human cancer
title Interferon regulatory factor 1 inactivation in human cancer
title_full Interferon regulatory factor 1 inactivation in human cancer
title_fullStr Interferon regulatory factor 1 inactivation in human cancer
title_full_unstemmed Interferon regulatory factor 1 inactivation in human cancer
title_short Interferon regulatory factor 1 inactivation in human cancer
title_sort interferon regulatory factor 1 inactivation in human cancer
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938431/
https://www.ncbi.nlm.nih.gov/pubmed/29599126
http://dx.doi.org/10.1042/BSR20171672
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