The First Case of Non-leukemic Sarcoma Composed of Mixed-phenotype Acute Leukemia, B/myeloid, Not Otherwise Specified

Isolated sarcoma with features of mixed-phenotype acute leukemia (MPAL) is an extremely rare disease and it can be easily misdiagnosed as lymphoma or other malignancies. We herein report the case of a 61-year-old woman with non-leukemic sarcoma of the right pleura, pretracheal lymph node, and suprac...

Descripción completa

Detalles Bibliográficos
Autores principales: Takakuwa, Teruhito, Nakane, Takahiko, Ohsawa, Masahiko, Nagasaki, Joji, Aoyama, Yasutaka, Nishimoto, Mistutaka, Hayashi, Yoshiki, Kuwae, Yuko, Hino, Masayuki, Nakamae, Hirohisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938510/
https://www.ncbi.nlm.nih.gov/pubmed/29269643
http://dx.doi.org/10.2169/internalmedicine.9144-17
_version_ 1783320798756339712
author Takakuwa, Teruhito
Nakane, Takahiko
Ohsawa, Masahiko
Nagasaki, Joji
Aoyama, Yasutaka
Nishimoto, Mistutaka
Hayashi, Yoshiki
Kuwae, Yuko
Hino, Masayuki
Nakamae, Hirohisa
author_facet Takakuwa, Teruhito
Nakane, Takahiko
Ohsawa, Masahiko
Nagasaki, Joji
Aoyama, Yasutaka
Nishimoto, Mistutaka
Hayashi, Yoshiki
Kuwae, Yuko
Hino, Masayuki
Nakamae, Hirohisa
author_sort Takakuwa, Teruhito
collection PubMed
description Isolated sarcoma with features of mixed-phenotype acute leukemia (MPAL) is an extremely rare disease and it can be easily misdiagnosed as lymphoma or other malignancies. We herein report the case of a 61-year-old woman with non-leukemic sarcoma of the right pleura, pretracheal lymph node, and supraclavicular lymph node with features of MPAL, B/myeloid, not otherwise specified, which was first misdiagnosed as diffuse large B cell lymphoma. After performing a detailed re-examination of the biopsy specimens, few scattered eosinophilic myelocytes allowed us to reach a correct diagnosis of MPAL and the patient was thereafter successfully treated by intensified chemotherapy followed by cord blood transplantation.
format Online
Article
Text
id pubmed-5938510
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-59385102018-05-08 The First Case of Non-leukemic Sarcoma Composed of Mixed-phenotype Acute Leukemia, B/myeloid, Not Otherwise Specified Takakuwa, Teruhito Nakane, Takahiko Ohsawa, Masahiko Nagasaki, Joji Aoyama, Yasutaka Nishimoto, Mistutaka Hayashi, Yoshiki Kuwae, Yuko Hino, Masayuki Nakamae, Hirohisa Intern Med Case Report Isolated sarcoma with features of mixed-phenotype acute leukemia (MPAL) is an extremely rare disease and it can be easily misdiagnosed as lymphoma or other malignancies. We herein report the case of a 61-year-old woman with non-leukemic sarcoma of the right pleura, pretracheal lymph node, and supraclavicular lymph node with features of MPAL, B/myeloid, not otherwise specified, which was first misdiagnosed as diffuse large B cell lymphoma. After performing a detailed re-examination of the biopsy specimens, few scattered eosinophilic myelocytes allowed us to reach a correct diagnosis of MPAL and the patient was thereafter successfully treated by intensified chemotherapy followed by cord blood transplantation. The Japanese Society of Internal Medicine 2017-12-21 2018-04-15 /pmc/articles/PMC5938510/ /pubmed/29269643 http://dx.doi.org/10.2169/internalmedicine.9144-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Takakuwa, Teruhito
Nakane, Takahiko
Ohsawa, Masahiko
Nagasaki, Joji
Aoyama, Yasutaka
Nishimoto, Mistutaka
Hayashi, Yoshiki
Kuwae, Yuko
Hino, Masayuki
Nakamae, Hirohisa
The First Case of Non-leukemic Sarcoma Composed of Mixed-phenotype Acute Leukemia, B/myeloid, Not Otherwise Specified
title The First Case of Non-leukemic Sarcoma Composed of Mixed-phenotype Acute Leukemia, B/myeloid, Not Otherwise Specified
title_full The First Case of Non-leukemic Sarcoma Composed of Mixed-phenotype Acute Leukemia, B/myeloid, Not Otherwise Specified
title_fullStr The First Case of Non-leukemic Sarcoma Composed of Mixed-phenotype Acute Leukemia, B/myeloid, Not Otherwise Specified
title_full_unstemmed The First Case of Non-leukemic Sarcoma Composed of Mixed-phenotype Acute Leukemia, B/myeloid, Not Otherwise Specified
title_short The First Case of Non-leukemic Sarcoma Composed of Mixed-phenotype Acute Leukemia, B/myeloid, Not Otherwise Specified
title_sort first case of non-leukemic sarcoma composed of mixed-phenotype acute leukemia, b/myeloid, not otherwise specified
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938510/
https://www.ncbi.nlm.nih.gov/pubmed/29269643
http://dx.doi.org/10.2169/internalmedicine.9144-17
work_keys_str_mv AT takakuwateruhito thefirstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT nakanetakahiko thefirstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT ohsawamasahiko thefirstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT nagasakijoji thefirstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT aoyamayasutaka thefirstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT nishimotomistutaka thefirstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT hayashiyoshiki thefirstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT kuwaeyuko thefirstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT hinomasayuki thefirstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT nakamaehirohisa thefirstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT takakuwateruhito firstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT nakanetakahiko firstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT ohsawamasahiko firstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT nagasakijoji firstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT aoyamayasutaka firstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT nishimotomistutaka firstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT hayashiyoshiki firstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT kuwaeyuko firstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT hinomasayuki firstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified
AT nakamaehirohisa firstcaseofnonleukemicsarcomacomposedofmixedphenotypeacuteleukemiabmyeloidnototherwisespecified

Ejemplares similares