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Dexmedetomidine inhibits inflammation in microglia cells under stimulation of LPS and ATP by c-Fos/NLRP3/caspase-1 cascades

NOD-like receptor 3 (NLRP3) plays critical roles in the initiation of inflammasome-mediated inflammation in microglia, thus becomes an important therapeutic target of Alzheimer's disease (AD). Dexmedetomidine (Dex), a new type of clinical anesthetic agent, shows anti-inflammatory properties and...

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Detalles Bibliográficos
Autores principales:	Li, Hu, Zhang, Xueping, Chen, Mingfu, Chen, Jianyan, Gao, Tao, Yao, Shanglong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Leibniz Research Centre for Working Environment and Human Factors 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938529/ https://www.ncbi.nlm.nih.gov/pubmed/29743866 http://dx.doi.org/10.17179/excli2017-1018

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