Mutations in the P10 region of procaspase-8 lead to chemotherapy resistance in acute myeloid leukemia by impairing procaspase-8 dimerization

Caspase-8 activation initiates apoptotic signaling cascades, and certain mutations in procasepase-8 have been reported to be associated with the progression and prognosis of different types of tumors. In this study, we have identified four novel mutations, which are highly correlated with chemothera...

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Detalles Bibliográficos
Autores principales: Li, Ming, Wu, Xiao-Mo, Gao, Ju, Yang, Fen, Zhang, Cui-Lin, Ke, Kun, Wang, Ying-Chao, Zheng, You-Shi, Yao, Jian-Feng, Guan, Ying-Ying, Chen, Xuan, Chen, Juan, Liu, Xiao-Long, Yang, Xiao-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938697/
https://www.ncbi.nlm.nih.gov/pubmed/29725008
http://dx.doi.org/10.1038/s41419-018-0511-3

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