SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment

Neutral sphingomyelinase smpd3 is most abundantly expressed in neurons of brain. The function of SMPD3 has remained elusive. Here, we report a pathogenetic nexus between absence of SMPD3 in the Golgi compartment (GC) of neurons of the smpd3-/- mouse brain, inhibition of Golgi vesicular protein trans...

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Detalles Bibliográficos
Autores principales: Stoffel, Wilhelm, Jenke, Britta, Schmidt-Soltau, Inga, Binczek, Erika, Brodesser, Susanne, Hammels, Ina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938706/
https://www.ncbi.nlm.nih.gov/pubmed/29725009
http://dx.doi.org/10.1038/s41419-018-0560-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938706/
https://www.ncbi.nlm.nih.gov/pubmed/29725009
http://dx.doi.org/10.1038/s41419-018-0560-7

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