Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix

Piezo proteins form mechanically activated ion channels that are responsible for our sense of light touch, proprioception, and vascular blood flow. Upon activation by mechanical stimuli, Piezo channels rapidly inactivate in a voltage-dependent manner through an unknown mechanism. Inactivation of Pie...

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Detalles Bibliográficos
Autores principales: Wu, Jason, Young, Michael, Lewis, Amanda H., Martfeld, Ashley N., Kalmeta, Breanna, Grandl, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938756/
https://www.ncbi.nlm.nih.gov/pubmed/29186675
http://dx.doi.org/10.1016/j.celrep.2017.10.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938756/
https://www.ncbi.nlm.nih.gov/pubmed/29186675
http://dx.doi.org/10.1016/j.celrep.2017.10.120

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