Cerebrospinal Fluid Immunoglobulins as Potential Biomarkers of Chikungunya Encephalitis

Chikungunya virus causes fever and severe polyarthritis or arthralgia and is associated with neurologic manifestations that are sometimes challenging to diagnose. We demonstrate intrathecal synthesis of chikungunya antibodies in a patient with a history of acute infection complicated by encephalitis...

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Detalles Bibliográficos
Autores principales: Puccioni-Sohler, Marzia, Farias, Luiz Claudio, Cabral-Castro, Mauro Jorge, Zalis, Mariano G., Kalil, Rosangela S., Salgado, Maria Cecília F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938764/
https://www.ncbi.nlm.nih.gov/pubmed/29664389
http://dx.doi.org/10.3201/eid2405.171763
Descripción
Sumario:Chikungunya virus causes fever and severe polyarthritis or arthralgia and is associated with neurologic manifestations that are sometimes challenging to diagnose. We demonstrate intrathecal synthesis of chikungunya antibodies in a patient with a history of acute infection complicated by encephalitis. The specificity of the intracerebral immune response supports early chikungunya-associated encephalitis diagnosis.

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