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Evaluation of Quantitative and Qualitative Renal Outcome Following Nephron Sparing Surgery
PURPOSE: Preservation of renal function after nephron-sparing surgery (NSS) is multifactorial and the impact of individual factors on it is still a debate. This prospective study investigates the impact of factors responsible for quantitative and functional outcome after NSS. PATIENTS AND METHODS: F...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939037/ https://www.ncbi.nlm.nih.gov/pubmed/29770263 http://dx.doi.org/10.4103/jcis.JCIS_82_17 |
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author | Choudhary, Gautam Ram Mandal, Arup Kumar Mete, Uttam Mavuduru, Ravimohan Bhatacharia, Anish Lal, Anupam Goyal, Suresh |
author_facet | Choudhary, Gautam Ram Mandal, Arup Kumar Mete, Uttam Mavuduru, Ravimohan Bhatacharia, Anish Lal, Anupam Goyal, Suresh |
author_sort | Choudhary, Gautam Ram |
collection | PubMed |
description | PURPOSE: Preservation of renal function after nephron-sparing surgery (NSS) is multifactorial and the impact of individual factors on it is still a debate. This prospective study investigates the impact of factors responsible for quantitative and functional outcome after NSS. PATIENTS AND METHODS: Fifty-two patients of localized renal mass (≤7 cm) were included in the study. A contrast-enhanced computed tomography abdomen was performed for characterization of tumor. Glomerular filtration rate (GFR) was calculated using Tc99m-diethylenetriamine pentaacetic acid (DTPA) scan and Cockcroft-Gault (CG) formula. All relevant intra- and peri-operative events were noted. Follow-up work up performed at 3 months. RESULTS: Overall, the mean ischemia time was 30.6 min, with 7.7% decrease in renal volume in the operated moiety. In follow-up, the total and ipsilateral GFR decreased. Change in renal parenchymal volume, total GFR by CG and DTPA, split GFR of tumor-bearing moiety was significant in follow-up. Size, stage, polar location of tumor, duration of surgery, type of ischemia, preoperative chronic kidney disease, and need of blood transfusion did not affect change in renal volume and function in the follow-up period. CONCLUSION: Renal parenchymal loss and duration of ischemia have impact on the follow-up renal function. |
format | Online Article Text |
id | pubmed-5939037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59390372018-05-16 Evaluation of Quantitative and Qualitative Renal Outcome Following Nephron Sparing Surgery Choudhary, Gautam Ram Mandal, Arup Kumar Mete, Uttam Mavuduru, Ravimohan Bhatacharia, Anish Lal, Anupam Goyal, Suresh J Clin Imaging Sci Original Article PURPOSE: Preservation of renal function after nephron-sparing surgery (NSS) is multifactorial and the impact of individual factors on it is still a debate. This prospective study investigates the impact of factors responsible for quantitative and functional outcome after NSS. PATIENTS AND METHODS: Fifty-two patients of localized renal mass (≤7 cm) were included in the study. A contrast-enhanced computed tomography abdomen was performed for characterization of tumor. Glomerular filtration rate (GFR) was calculated using Tc99m-diethylenetriamine pentaacetic acid (DTPA) scan and Cockcroft-Gault (CG) formula. All relevant intra- and peri-operative events were noted. Follow-up work up performed at 3 months. RESULTS: Overall, the mean ischemia time was 30.6 min, with 7.7% decrease in renal volume in the operated moiety. In follow-up, the total and ipsilateral GFR decreased. Change in renal parenchymal volume, total GFR by CG and DTPA, split GFR of tumor-bearing moiety was significant in follow-up. Size, stage, polar location of tumor, duration of surgery, type of ischemia, preoperative chronic kidney disease, and need of blood transfusion did not affect change in renal volume and function in the follow-up period. CONCLUSION: Renal parenchymal loss and duration of ischemia have impact on the follow-up renal function. Medknow Publications & Media Pvt Ltd 2018-04-16 /pmc/articles/PMC5939037/ /pubmed/29770263 http://dx.doi.org/10.4103/jcis.JCIS_82_17 Text en Copyright: © 2018 Journal of Clinical Imaging Science http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Choudhary, Gautam Ram Mandal, Arup Kumar Mete, Uttam Mavuduru, Ravimohan Bhatacharia, Anish Lal, Anupam Goyal, Suresh Evaluation of Quantitative and Qualitative Renal Outcome Following Nephron Sparing Surgery |
title | Evaluation of Quantitative and Qualitative Renal Outcome Following Nephron Sparing Surgery |
title_full | Evaluation of Quantitative and Qualitative Renal Outcome Following Nephron Sparing Surgery |
title_fullStr | Evaluation of Quantitative and Qualitative Renal Outcome Following Nephron Sparing Surgery |
title_full_unstemmed | Evaluation of Quantitative and Qualitative Renal Outcome Following Nephron Sparing Surgery |
title_short | Evaluation of Quantitative and Qualitative Renal Outcome Following Nephron Sparing Surgery |
title_sort | evaluation of quantitative and qualitative renal outcome following nephron sparing surgery |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939037/ https://www.ncbi.nlm.nih.gov/pubmed/29770263 http://dx.doi.org/10.4103/jcis.JCIS_82_17 |
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