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A Retrospective Study to Compare Five Induction Chemotherapy Regimens Prior to Radiotherapy in the Reduction of Regional Lymph Node Size in Patients with Nasopharyngeal Carcinoma

BACKGROUND: Combined chemotherapy and radiation therapy are used to treat nasopharyngeal carcinoma (NPC). Previous studies have shown that induction chemotherapy, given before radiotherapy, is beneficial in patients with local lymph node metastases. The aim of this study was to evaluate regional lym...

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Autores principales: Chen, Jing, Qi, Ji, Yu, Bo-Long, Peng, Xiao-Hong, Wang, Fan, Tan, Jia-Jie, Chen, Qi-Qian, Peng, Xin-Yu, Zeng, Fang-Fang, Liu, Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939706/
https://www.ncbi.nlm.nih.gov/pubmed/29697098
http://dx.doi.org/10.12659/MSM.906625
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author Chen, Jing
Qi, Ji
Yu, Bo-Long
Peng, Xiao-Hong
Wang, Fan
Tan, Jia-Jie
Chen, Qi-Qian
Peng, Xin-Yu
Zeng, Fang-Fang
Liu, Xiong
author_facet Chen, Jing
Qi, Ji
Yu, Bo-Long
Peng, Xiao-Hong
Wang, Fan
Tan, Jia-Jie
Chen, Qi-Qian
Peng, Xin-Yu
Zeng, Fang-Fang
Liu, Xiong
author_sort Chen, Jing
collection PubMed
description BACKGROUND: Combined chemotherapy and radiation therapy are used to treat nasopharyngeal carcinoma (NPC). Previous studies have shown that induction chemotherapy, given before radiotherapy, is beneficial in patients with local lymph node metastases. The aim of this study was to evaluate regional lymph node size in patients with NPC and the efficacy of five induction chemotherapy regimens given before radiotherapy. MATERIAL/METHODS: Between December 2007 and June 2011, 190 patients were included in this study, who had regionally advanced NPC (Stages II–IV). Five induction chemotherapy regimens were given prior to radiation: 98 patients (51.6%) received the TPF regimen (docetaxel, cisplatin, and fluorouracil); 56 patients (29.5%) received PF regimen (cisplatin and fluorouracil); 26 patients (13.7%) received the TP regimen (cisplatin and docetaxel); seven patients (3.7%) received combined nimotuzumab with TPF; three patients (1.6%) received a combination of the novel modified recombinant human endostatin (Endostar) with PF. The length and width of the regional lymph nodes were measured using neck B-mode (high-resolution grey scale) ultrasonography before chemotherapy and on the second day following completion of chemotherapy. Gastrointestinal tract and bone marrow suppression were also monitored during and after chemotherapy. RESULTS: The TPF chemotherapy induction regimen resulted in an improved early response of lymph node size reduction, compared with the PF and TP chemotherapy induction regimens. The combined use of nimotuzumab with the TPF regimen improved efficacy by 15%. The combined use of Endostar improved the efficacy of the PF regimen by 56% (P<0.05). CONCLUSIONS: In a retrospective study in patients with NPC, different induction chemotherapy regimens had different effects on lymph node size before radiation therapy.
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spelling pubmed-59397062018-05-09 A Retrospective Study to Compare Five Induction Chemotherapy Regimens Prior to Radiotherapy in the Reduction of Regional Lymph Node Size in Patients with Nasopharyngeal Carcinoma Chen, Jing Qi, Ji Yu, Bo-Long Peng, Xiao-Hong Wang, Fan Tan, Jia-Jie Chen, Qi-Qian Peng, Xin-Yu Zeng, Fang-Fang Liu, Xiong Med Sci Monit Clinical Research BACKGROUND: Combined chemotherapy and radiation therapy are used to treat nasopharyngeal carcinoma (NPC). Previous studies have shown that induction chemotherapy, given before radiotherapy, is beneficial in patients with local lymph node metastases. The aim of this study was to evaluate regional lymph node size in patients with NPC and the efficacy of five induction chemotherapy regimens given before radiotherapy. MATERIAL/METHODS: Between December 2007 and June 2011, 190 patients were included in this study, who had regionally advanced NPC (Stages II–IV). Five induction chemotherapy regimens were given prior to radiation: 98 patients (51.6%) received the TPF regimen (docetaxel, cisplatin, and fluorouracil); 56 patients (29.5%) received PF regimen (cisplatin and fluorouracil); 26 patients (13.7%) received the TP regimen (cisplatin and docetaxel); seven patients (3.7%) received combined nimotuzumab with TPF; three patients (1.6%) received a combination of the novel modified recombinant human endostatin (Endostar) with PF. The length and width of the regional lymph nodes were measured using neck B-mode (high-resolution grey scale) ultrasonography before chemotherapy and on the second day following completion of chemotherapy. Gastrointestinal tract and bone marrow suppression were also monitored during and after chemotherapy. RESULTS: The TPF chemotherapy induction regimen resulted in an improved early response of lymph node size reduction, compared with the PF and TP chemotherapy induction regimens. The combined use of nimotuzumab with the TPF regimen improved efficacy by 15%. The combined use of Endostar improved the efficacy of the PF regimen by 56% (P<0.05). CONCLUSIONS: In a retrospective study in patients with NPC, different induction chemotherapy regimens had different effects on lymph node size before radiation therapy. International Scientific Literature, Inc. 2018-04-26 /pmc/articles/PMC5939706/ /pubmed/29697098 http://dx.doi.org/10.12659/MSM.906625 Text en © Med Sci Monit, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Clinical Research
Chen, Jing
Qi, Ji
Yu, Bo-Long
Peng, Xiao-Hong
Wang, Fan
Tan, Jia-Jie
Chen, Qi-Qian
Peng, Xin-Yu
Zeng, Fang-Fang
Liu, Xiong
A Retrospective Study to Compare Five Induction Chemotherapy Regimens Prior to Radiotherapy in the Reduction of Regional Lymph Node Size in Patients with Nasopharyngeal Carcinoma
title A Retrospective Study to Compare Five Induction Chemotherapy Regimens Prior to Radiotherapy in the Reduction of Regional Lymph Node Size in Patients with Nasopharyngeal Carcinoma
title_full A Retrospective Study to Compare Five Induction Chemotherapy Regimens Prior to Radiotherapy in the Reduction of Regional Lymph Node Size in Patients with Nasopharyngeal Carcinoma
title_fullStr A Retrospective Study to Compare Five Induction Chemotherapy Regimens Prior to Radiotherapy in the Reduction of Regional Lymph Node Size in Patients with Nasopharyngeal Carcinoma
title_full_unstemmed A Retrospective Study to Compare Five Induction Chemotherapy Regimens Prior to Radiotherapy in the Reduction of Regional Lymph Node Size in Patients with Nasopharyngeal Carcinoma
title_short A Retrospective Study to Compare Five Induction Chemotherapy Regimens Prior to Radiotherapy in the Reduction of Regional Lymph Node Size in Patients with Nasopharyngeal Carcinoma
title_sort retrospective study to compare five induction chemotherapy regimens prior to radiotherapy in the reduction of regional lymph node size in patients with nasopharyngeal carcinoma
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939706/
https://www.ncbi.nlm.nih.gov/pubmed/29697098
http://dx.doi.org/10.12659/MSM.906625
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