Construction of histidine-containing hydrocarbon stapled cell penetrating peptides for in vitro and in vivo delivery of siRNAs

A hydrocarbon stapled peptide based strategy was used to develop an optimized cell penetrating peptide for siRNA delivery. Various stapled peptides, having amphipathic Leu- and Lys-rich regions, were prepared and their cell penetrating potentials were evaluated. One peptide, stEK, was found to have...

Descripción completa

Detalles Bibliográficos
Autores principales: Hyun, Soonsil, Choi, Yoonhwa, Lee, Ha Neul, Lee, Changki, Oh, Donghoon, Lee, Dong-Ki, Lee, Changjin, Lee, Yan, Yu, Jaehoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939838/
https://www.ncbi.nlm.nih.gov/pubmed/29780514
http://dx.doi.org/10.1039/c8sc00074c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939838/
https://www.ncbi.nlm.nih.gov/pubmed/29780514
http://dx.doi.org/10.1039/c8sc00074c

Ejemplares similares