KCNQ1OT1 promotes melanoma growth and metastasis

Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demon...

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Detalles Bibliográficos
Autores principales: Guo, Bingyu, Zhang, Qian, Wang, Hongyi, Chang, Peng, Tao, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940105/
https://www.ncbi.nlm.nih.gov/pubmed/29667930
http://dx.doi.org/10.18632/aging.101418
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author Guo, Bingyu
Zhang, Qian
Wang, Hongyi
Chang, Peng
Tao, Kai
author_facet Guo, Bingyu
Zhang, Qian
Wang, Hongyi
Chang, Peng
Tao, Kai
author_sort Guo, Bingyu
collection PubMed
description Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1OT1 expression is up-regulated in melanoma tissues and cells. KCNQ1OT1 promoted cell proliferation and metastasis in melanoma. By directly bindin to miR-153, KCNQ1OT1 acted as a competing endogenous RNA (ceRNA) to de-repress MET expression. Our results may provide the basis for a novel strategy for early detection and/or treatment of melanoma.
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spelling pubmed-59401052018-05-14 KCNQ1OT1 promotes melanoma growth and metastasis Guo, Bingyu Zhang, Qian Wang, Hongyi Chang, Peng Tao, Kai Aging (Albany NY) Research Paper Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1OT1 expression is up-regulated in melanoma tissues and cells. KCNQ1OT1 promoted cell proliferation and metastasis in melanoma. By directly bindin to miR-153, KCNQ1OT1 acted as a competing endogenous RNA (ceRNA) to de-repress MET expression. Our results may provide the basis for a novel strategy for early detection and/or treatment of melanoma. Impact Journals 2018-04-17 /pmc/articles/PMC5940105/ /pubmed/29667930 http://dx.doi.org/10.18632/aging.101418 Text en Copyright © 2018 Guo et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Guo, Bingyu
Zhang, Qian
Wang, Hongyi
Chang, Peng
Tao, Kai
KCNQ1OT1 promotes melanoma growth and metastasis
title KCNQ1OT1 promotes melanoma growth and metastasis
title_full KCNQ1OT1 promotes melanoma growth and metastasis
title_fullStr KCNQ1OT1 promotes melanoma growth and metastasis
title_full_unstemmed KCNQ1OT1 promotes melanoma growth and metastasis
title_short KCNQ1OT1 promotes melanoma growth and metastasis
title_sort kcnq1ot1 promotes melanoma growth and metastasis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940105/
https://www.ncbi.nlm.nih.gov/pubmed/29667930
http://dx.doi.org/10.18632/aging.101418
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