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Statins impact primary embryonic mouse neural stem cell survival, cell death, and fate through distinct mechanisms
Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in the cholesterol biosynthesis pathway (CBP), and are used for the prevention of cardiovascular disease. The anti-inflammatory effects of statins may also provide therapeutic benefits and have led to their use in clinical trials for preecl...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940229/ https://www.ncbi.nlm.nih.gov/pubmed/29738536 http://dx.doi.org/10.1371/journal.pone.0196387 |