Cargando…
The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
Detection of microbial DNA is an evolutionarily conserved mechanism that alerts the host immune system to mount a defense response to microbial infections. However, this detection mechanism also poses a challenge to the host as to how to distinguish foreign DNA from abundant self-DNA. Cyclic guanosi...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940270/ https://www.ncbi.nlm.nih.gov/pubmed/29622565 http://dx.doi.org/10.1084/jem.20180139 |