Repressing the repressor: Ezh2 mediates macrophage activation

In this issue of JEM, Zhang et al. (https://doi.org/10.1084/jem.20171417) show that the suppressive epigenetic enzyme Ezh2 is an important regulator of macrophage activation. The absence of Ezh2 leads to reduced cytokine secretion and suppresses macrophage-dependent disease development. They identif...

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Detalles Bibliográficos
Autores principales: Neele, Annette E., de Winther, Menno P.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940273/
https://www.ncbi.nlm.nih.gov/pubmed/29691302
http://dx.doi.org/10.1084/jem.20180479
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author Neele, Annette E.
de Winther, Menno P.J.
author_facet Neele, Annette E.
de Winther, Menno P.J.
author_sort Neele, Annette E.
collection PubMed
description In this issue of JEM, Zhang et al. (https://doi.org/10.1084/jem.20171417) show that the suppressive epigenetic enzyme Ezh2 is an important regulator of macrophage activation. The absence of Ezh2 leads to reduced cytokine secretion and suppresses macrophage-dependent disease development. They identify the antiinflammatory factor Socs3 as an important target for Ezh2 and thus show that regulation of suppressive histone modifications controls macrophage activation in disease.
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spelling pubmed-59402732018-11-07 Repressing the repressor: Ezh2 mediates macrophage activation Neele, Annette E. de Winther, Menno P.J. J Exp Med News In this issue of JEM, Zhang et al. (https://doi.org/10.1084/jem.20171417) show that the suppressive epigenetic enzyme Ezh2 is an important regulator of macrophage activation. The absence of Ezh2 leads to reduced cytokine secretion and suppresses macrophage-dependent disease development. They identify the antiinflammatory factor Socs3 as an important target for Ezh2 and thus show that regulation of suppressive histone modifications controls macrophage activation in disease. Rockefeller University Press 2018-05-07 /pmc/articles/PMC5940273/ /pubmed/29691302 http://dx.doi.org/10.1084/jem.20180479 Text en © 2018 Neele and de Winther http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle News
Neele, Annette E.
de Winther, Menno P.J.
Repressing the repressor: Ezh2 mediates macrophage activation
title Repressing the repressor: Ezh2 mediates macrophage activation
title_full Repressing the repressor: Ezh2 mediates macrophage activation
title_fullStr Repressing the repressor: Ezh2 mediates macrophage activation
title_full_unstemmed Repressing the repressor: Ezh2 mediates macrophage activation
title_short Repressing the repressor: Ezh2 mediates macrophage activation
title_sort repressing the repressor: ezh2 mediates macrophage activation
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940273/
https://www.ncbi.nlm.nih.gov/pubmed/29691302
http://dx.doi.org/10.1084/jem.20180479
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