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Mechanotransduction in tumor progression: The dark side of the force

Cancer has been characterized as a genetic disease, associated with mutations that cause pathological alterations of the cell cycle, adhesion, or invasive motility. Recently, the importance of the anomalous mechanical properties of tumor tissues, which activate tumorigenic biochemical pathways, has...

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Autores principales: Broders-Bondon, Florence, Nguyen Ho-Bouldoires, Thanh Huong, Fernandez-Sanchez, Maria-Elena, Farge, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940296/
https://www.ncbi.nlm.nih.gov/pubmed/29467174
http://dx.doi.org/10.1083/jcb.201701039
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author Broders-Bondon, Florence
Nguyen Ho-Bouldoires, Thanh Huong
Fernandez-Sanchez, Maria-Elena
Farge, Emmanuel
author_facet Broders-Bondon, Florence
Nguyen Ho-Bouldoires, Thanh Huong
Fernandez-Sanchez, Maria-Elena
Farge, Emmanuel
author_sort Broders-Bondon, Florence
collection PubMed
description Cancer has been characterized as a genetic disease, associated with mutations that cause pathological alterations of the cell cycle, adhesion, or invasive motility. Recently, the importance of the anomalous mechanical properties of tumor tissues, which activate tumorigenic biochemical pathways, has become apparent. This mechanical induction in tumors appears to consist of the destabilization of adult tissue homeostasis as a result of the reactivation of embryonic developmental mechanosensitive pathways in response to pathological mechanical strains. These strains occur in many forms, for example, hypervascularization in late tumors leads to high static hydrodynamic pressure that can promote malignant progression through hypoxia or anomalous interstitial liquid and blood flow. The high stiffness of tumors directly induces the mechanical activation of biochemical pathways enhancing the cell cycle, epithelial–mesenchymal transition, and cell motility. Furthermore, increases in solid-stress pressure associated with cell hyperproliferation activate tumorigenic pathways in the healthy epithelial cells compressed by the neighboring tumor. The underlying molecular mechanisms of the translation of a mechanical signal into a tumor inducing biochemical signal are based on mechanically induced protein conformational changes that activate classical tumorigenic signaling pathways. Understanding these mechanisms will be important for the development of innovative treatments to target such mechanical anomalies in cancer.
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spelling pubmed-59402962018-11-07 Mechanotransduction in tumor progression: The dark side of the force Broders-Bondon, Florence Nguyen Ho-Bouldoires, Thanh Huong Fernandez-Sanchez, Maria-Elena Farge, Emmanuel J Cell Biol Reviews Cancer has been characterized as a genetic disease, associated with mutations that cause pathological alterations of the cell cycle, adhesion, or invasive motility. Recently, the importance of the anomalous mechanical properties of tumor tissues, which activate tumorigenic biochemical pathways, has become apparent. This mechanical induction in tumors appears to consist of the destabilization of adult tissue homeostasis as a result of the reactivation of embryonic developmental mechanosensitive pathways in response to pathological mechanical strains. These strains occur in many forms, for example, hypervascularization in late tumors leads to high static hydrodynamic pressure that can promote malignant progression through hypoxia or anomalous interstitial liquid and blood flow. The high stiffness of tumors directly induces the mechanical activation of biochemical pathways enhancing the cell cycle, epithelial–mesenchymal transition, and cell motility. Furthermore, increases in solid-stress pressure associated with cell hyperproliferation activate tumorigenic pathways in the healthy epithelial cells compressed by the neighboring tumor. The underlying molecular mechanisms of the translation of a mechanical signal into a tumor inducing biochemical signal are based on mechanically induced protein conformational changes that activate classical tumorigenic signaling pathways. Understanding these mechanisms will be important for the development of innovative treatments to target such mechanical anomalies in cancer. Rockefeller University Press 2018-05-07 /pmc/articles/PMC5940296/ /pubmed/29467174 http://dx.doi.org/10.1083/jcb.201701039 Text en © 2018 Broders-Bondon et al. http://www.rupress.org/termshttps://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms (http://www.rupress.org/terms/) ). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Broders-Bondon, Florence
Nguyen Ho-Bouldoires, Thanh Huong
Fernandez-Sanchez, Maria-Elena
Farge, Emmanuel
Mechanotransduction in tumor progression: The dark side of the force
title Mechanotransduction in tumor progression: The dark side of the force
title_full Mechanotransduction in tumor progression: The dark side of the force
title_fullStr Mechanotransduction in tumor progression: The dark side of the force
title_full_unstemmed Mechanotransduction in tumor progression: The dark side of the force
title_short Mechanotransduction in tumor progression: The dark side of the force
title_sort mechanotransduction in tumor progression: the dark side of the force
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940296/
https://www.ncbi.nlm.nih.gov/pubmed/29467174
http://dx.doi.org/10.1083/jcb.201701039
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