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Lgr5(+) intestinal stem cells reside in an unlicensed G(1) phase
During late mitosis and the early G(1) phase, the origins of replication are licensed by binding to double hexamers of MCM2–7. In this study, we investigated how licensing and proliferative commitment are coupled in the epithelium of the small intestine. We developed a method for identifying cells i...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940300/ https://www.ncbi.nlm.nih.gov/pubmed/29599208 http://dx.doi.org/10.1083/jcb.201708023 |