Autophagy balances mtDNA synthesis and degradation by DNA polymerase POLG during starvation

Mitochondria contain tens to thousands of copies of their own genome (mitochondrial DNA [mtDNA]), creating genetic redundancy capable of buffering mutations in mitochondrial genes essential for cellular function. However, the mechanisms regulating mtDNA copy number have been elusive. Here we found t...

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Detalles Bibliográficos
Autores principales: Medeiros, Tânia Catarina, Thomas, Ryan Lee, Ghillebert, Ruben, Graef, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940314/
https://www.ncbi.nlm.nih.gov/pubmed/29519802
http://dx.doi.org/10.1083/jcb.201801168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940314/
https://www.ncbi.nlm.nih.gov/pubmed/29519802
http://dx.doi.org/10.1083/jcb.201801168

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