DNA replication licensing in stem cells: Gatekeeping the commitment to proliferation

Carroll et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201708023) developed a method to assess DNA replication licensing in tissues. They show that intestinal stem cells within wild-type crypts, but not in crypts with cancer-causing mutations, are largely unlicensed, suggesting that licensi...

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Detalles Bibliográficos
Autor principal: Coller, Hilary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940315/
https://www.ncbi.nlm.nih.gov/pubmed/29653996
http://dx.doi.org/10.1083/jcb.201803037
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author Coller, Hilary A.
author_facet Coller, Hilary A.
author_sort Coller, Hilary A.
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description Carroll et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201708023) developed a method to assess DNA replication licensing in tissues. They show that intestinal stem cells within wild-type crypts, but not in crypts with cancer-causing mutations, are largely unlicensed, suggesting that licensing may represent a rate-limiting step in the commitment to proliferation.
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spelling pubmed-59403152018-11-07 DNA replication licensing in stem cells: Gatekeeping the commitment to proliferation Coller, Hilary A. J Cell Biol Commentaries Carroll et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201708023) developed a method to assess DNA replication licensing in tissues. They show that intestinal stem cells within wild-type crypts, but not in crypts with cancer-causing mutations, are largely unlicensed, suggesting that licensing may represent a rate-limiting step in the commitment to proliferation. Rockefeller University Press 2018-05-07 /pmc/articles/PMC5940315/ /pubmed/29653996 http://dx.doi.org/10.1083/jcb.201803037 Text en © 2018 Coller http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Coller, Hilary A.
DNA replication licensing in stem cells: Gatekeeping the commitment to proliferation
title DNA replication licensing in stem cells: Gatekeeping the commitment to proliferation
title_full DNA replication licensing in stem cells: Gatekeeping the commitment to proliferation
title_fullStr DNA replication licensing in stem cells: Gatekeeping the commitment to proliferation
title_full_unstemmed DNA replication licensing in stem cells: Gatekeeping the commitment to proliferation
title_short DNA replication licensing in stem cells: Gatekeeping the commitment to proliferation
title_sort dna replication licensing in stem cells: gatekeeping the commitment to proliferation
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940315/
https://www.ncbi.nlm.nih.gov/pubmed/29653996
http://dx.doi.org/10.1083/jcb.201803037
work_keys_str_mv AT collerhilarya dnareplicationlicensinginstemcellsgatekeepingthecommitmenttoproliferation

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