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DNA replication licensing in stem cells: Gatekeeping the commitment to proliferation
Carroll et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201708023) developed a method to assess DNA replication licensing in tissues. They show that intestinal stem cells within wild-type crypts, but not in crypts with cancer-causing mutations, are largely unlicensed, suggesting that licensi...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940315/ https://www.ncbi.nlm.nih.gov/pubmed/29653996 http://dx.doi.org/10.1083/jcb.201803037 |