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Targeted nanoparticle delivery of therapeutic antisense microRNAs presensitizes glioblastoma cells to lower effective doses of temozolomide in vitro and in a mouse model

Temozolomide (TMZ) chemotherapy for glioblastoma (GBM) is generally well tolerated at standard doses but it can cause side effects. GBMs overexpress microRNA-21 and microRNA-10b, two known oncomiRs that promote cancer development, progression and resistance to drug treatment. We hypothesized that sy...

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Detalles Bibliográficos
Autores principales:	Malhotra, Meenakshi, Sekar, Thillai Veerapazham, Ananta, Jeyarama S., Devulapally, Rammohan, Afjei, Rayhaneh, Babikir, Husam A., Paulmurugan, Ramasamy, Massoud, Tarik F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940368/ https://www.ncbi.nlm.nih.gov/pubmed/29765554 http://dx.doi.org/10.18632/oncotarget.25135

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