Pharmacologic inhibition of STAT5 in acute myeloid leukemia

The transcription factor STAT5 is an essential downstream mediator of many tyrosine kinases (TKs), particularly in hematopoietic cancers. STAT5 is activated by FLT3-ITD, which is a constitutively active TK driving the pathogenesis of acute myeloid leukemia (AML). Since STAT5 is a critical mediator o...

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Detalles Bibliográficos
Autores principales: Wingelhofer, Bettina, Maurer, Barbara, Heyes, Elizabeth C., Cumaraswamy, Abbarna A., Berger-Becvar, Angelika, de Araujo, Elvin D., Orlova, Anna, Freund, Patricia, Ruge, Frank, Park, Jisung, Tin, Gary, Ahmar, Siawash, Lardeau, Charles-Hugues, Sadovnik, Irina, Bajusz, Dávid, Keserű, György Miklós, Grebien, Florian, Kubicek, Stefan, Valent, Peter, Gunning, Patrick T., Moriggl, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940656/
https://www.ncbi.nlm.nih.gov/pubmed/29472718
http://dx.doi.org/10.1038/s41375-017-0005-9

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