Cargando…

Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry

When considering life’s aetiology, the first questions that must be addressed are “how?” and “where?” were ostensibly complex molecules, considered necessary for life’s beginning, constructed from simpler, more abundant feedstock molecules on primitive Earth. Previously, we have used multiple clues...

Descripción completa

Detalles Bibliográficos
Autores principales: Ritson, Dougal J., Battilocchio, Claudio, Ley, Steven V., Sutherland, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940729/
https://www.ncbi.nlm.nih.gov/pubmed/29739945
http://dx.doi.org/10.1038/s41467-018-04147-2
_version_ 1783321142267740160
author Ritson, Dougal J.
Battilocchio, Claudio
Ley, Steven V.
Sutherland, John D.
author_facet Ritson, Dougal J.
Battilocchio, Claudio
Ley, Steven V.
Sutherland, John D.
author_sort Ritson, Dougal J.
collection PubMed
description When considering life’s aetiology, the first questions that must be addressed are “how?” and “where?” were ostensibly complex molecules, considered necessary for life’s beginning, constructed from simpler, more abundant feedstock molecules on primitive Earth. Previously, we have used multiple clues from the prebiotic synthetic requirements of (proto)biomolecules to pinpoint a set of closely related geochemical scenarios that are suggestive of flow and semi-batch chemistries. We now wish to report a multistep, uninterrupted synthesis of a key heterocycle (2-aminooxazole) en route to activated nucleotides starting from highly plausible, prebiotic feedstock molecules under conditions which mimic this scenario. Further consideration of the scenario has uncovered additional pertinent and novel aspects of prebiotic chemistry, which greatly enhance the efficiency and plausibility of the synthesis.
format Online
Article
Text
id pubmed-5940729
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-59407292018-05-10 Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry Ritson, Dougal J. Battilocchio, Claudio Ley, Steven V. Sutherland, John D. Nat Commun Article When considering life’s aetiology, the first questions that must be addressed are “how?” and “where?” were ostensibly complex molecules, considered necessary for life’s beginning, constructed from simpler, more abundant feedstock molecules on primitive Earth. Previously, we have used multiple clues from the prebiotic synthetic requirements of (proto)biomolecules to pinpoint a set of closely related geochemical scenarios that are suggestive of flow and semi-batch chemistries. We now wish to report a multistep, uninterrupted synthesis of a key heterocycle (2-aminooxazole) en route to activated nucleotides starting from highly plausible, prebiotic feedstock molecules under conditions which mimic this scenario. Further consideration of the scenario has uncovered additional pertinent and novel aspects of prebiotic chemistry, which greatly enhance the efficiency and plausibility of the synthesis. Nature Publishing Group UK 2018-05-08 /pmc/articles/PMC5940729/ /pubmed/29739945 http://dx.doi.org/10.1038/s41467-018-04147-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ritson, Dougal J.
Battilocchio, Claudio
Ley, Steven V.
Sutherland, John D.
Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry
title Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry
title_full Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry
title_fullStr Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry
title_full_unstemmed Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry
title_short Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry
title_sort mimicking the surface and prebiotic chemistry of early earth using flow chemistry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940729/
https://www.ncbi.nlm.nih.gov/pubmed/29739945
http://dx.doi.org/10.1038/s41467-018-04147-2
work_keys_str_mv AT ritsondougalj mimickingthesurfaceandprebioticchemistryofearlyearthusingflowchemistry
AT battilocchioclaudio mimickingthesurfaceandprebioticchemistryofearlyearthusingflowchemistry
AT leystevenv mimickingthesurfaceandprebioticchemistryofearlyearthusingflowchemistry
AT sutherlandjohnd mimickingthesurfaceandprebioticchemistryofearlyearthusingflowchemistry