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Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure
The skin’s tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously ide...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940788/ https://www.ncbi.nlm.nih.gov/pubmed/29739929 http://dx.doi.org/10.1038/s41467-018-04086-y |
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| author | Visconti, Alessia Duffy, David L. Liu, Fan Zhu, Gu Wu, Wenting Chen, Yan Hysi, Pirro G. Zeng, Changqing Sanna, Marianna Iles, Mark M. Kanetsky, Peter A. Demenais, Florence Hamer, Merel A. Uitterlinden, Andre G. Ikram, M. Arfan Nijsten, Tamar Martin, Nicholas G. Kayser, Manfred Spector, Tim D. Han, Jiali Bataille, Veronique Falchi, Mario |
| author_facet | Visconti, Alessia Duffy, David L. Liu, Fan Zhu, Gu Wu, Wenting Chen, Yan Hysi, Pirro G. Zeng, Changqing Sanna, Marianna Iles, Mark M. Kanetsky, Peter A. Demenais, Florence Hamer, Merel A. Uitterlinden, Andre G. Ikram, M. Arfan Nijsten, Tamar Martin, Nicholas G. Kayser, Manfred Spector, Tim D. Han, Jiali Bataille, Veronique Falchi, Mario |
| author_sort | Visconti, Alessia |
| collection | PubMed |
| description | The skin’s tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability. |
| format | Online Article Text |
| id | pubmed-5940788 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-59407882018-05-10 Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure Visconti, Alessia Duffy, David L. Liu, Fan Zhu, Gu Wu, Wenting Chen, Yan Hysi, Pirro G. Zeng, Changqing Sanna, Marianna Iles, Mark M. Kanetsky, Peter A. Demenais, Florence Hamer, Merel A. Uitterlinden, Andre G. Ikram, M. Arfan Nijsten, Tamar Martin, Nicholas G. Kayser, Manfred Spector, Tim D. Han, Jiali Bataille, Veronique Falchi, Mario Nat Commun Article The skin’s tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability. Nature Publishing Group UK 2018-05-08 /pmc/articles/PMC5940788/ /pubmed/29739929 http://dx.doi.org/10.1038/s41467-018-04086-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Visconti, Alessia Duffy, David L. Liu, Fan Zhu, Gu Wu, Wenting Chen, Yan Hysi, Pirro G. Zeng, Changqing Sanna, Marianna Iles, Mark M. Kanetsky, Peter A. Demenais, Florence Hamer, Merel A. Uitterlinden, Andre G. Ikram, M. Arfan Nijsten, Tamar Martin, Nicholas G. Kayser, Manfred Spector, Tim D. Han, Jiali Bataille, Veronique Falchi, Mario Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure |
| title | Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure |
| title_full | Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure |
| title_fullStr | Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure |
| title_full_unstemmed | Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure |
| title_short | Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure |
| title_sort | genome-wide association study in 176,678 europeans reveals genetic loci for tanning response to sun exposure |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940788/ https://www.ncbi.nlm.nih.gov/pubmed/29739929 http://dx.doi.org/10.1038/s41467-018-04086-y |
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