Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas

Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial−myoepithelial differentiation, whose genetic underpinning is largely unknown. Here we show through whole-exome and targeted massively parallel sequencing analysis that whilst estrogen receptor (ER)-positive adenomyoepithel...

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Detalles Bibliográficos
Autores principales: Geyer, Felipe C., Li, Anqi, Papanastasiou, Anastasios D., Smith, Alison, Selenica, Pier, Burke, Kathleen A., Edelweiss, Marcia, Wen, Huei-Chi, Piscuoglio, Salvatore, Schultheis, Anne M., Martelotto, Luciano G., Pareja, Fresia, Kumar, Rahul, Brandes, Alissa, Fan, Dan, Basili, Thais, Da Cruz Paula, Arnaud, Lozada, John R., Blecua, Pedro, Muenst, Simone, Jungbluth, Achim A., Foschini, Maria P., Wen, Hannah Y., Brogi, Edi, Palazzo, Juan, Rubin, Brian P., Ng, Charlotte K. Y., Norton, Larry, Varga, Zsuzsanna, Ellis, Ian O., Rakha, Emad A., Chandarlapaty, Sarat, Weigelt, Britta, Reis-Filho, Jorge S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940840/
https://www.ncbi.nlm.nih.gov/pubmed/29739933
http://dx.doi.org/10.1038/s41467-018-04128-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940840/
https://www.ncbi.nlm.nih.gov/pubmed/29739933
http://dx.doi.org/10.1038/s41467-018-04128-5

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