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Using all-cause mortality to define severe RV dilation with RV/LV volume ratio

Right ventricular (RV) end-diastolic volume (EDV) to left ventricular (LV) EDV ratio using cardiovascular magnetic resonance imaging (CMR) is an important parameter for RV size evaluation in additional to indexed EDV. We explore the severity partition for RV dilation using mortality in a population...

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Autores principales: Altmayer, Stephan P. L., Han, Q. Joyce, Addetia, Karima, Patel, Amit R., Forfia, Paul R., Han, Yuchi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940893/
https://www.ncbi.nlm.nih.gov/pubmed/29739967
http://dx.doi.org/10.1038/s41598-018-25259-1
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author Altmayer, Stephan P. L.
Han, Q. Joyce
Addetia, Karima
Patel, Amit R.
Forfia, Paul R.
Han, Yuchi
author_facet Altmayer, Stephan P. L.
Han, Q. Joyce
Addetia, Karima
Patel, Amit R.
Forfia, Paul R.
Han, Yuchi
author_sort Altmayer, Stephan P. L.
collection PubMed
description Right ventricular (RV) end-diastolic volume (EDV) to left ventricular (LV) EDV ratio using cardiovascular magnetic resonance imaging (CMR) is an important parameter for RV size evaluation in additional to indexed EDV. We explore the severity partition for RV dilation using mortality in a population of 62 patients with pulmonary hypertension (PH). Cine short-axis images were acquired with a 1.5 T MR scanner using a steady-state free precession sequence. The optimal cutoff to classify severe RV dilation was determined by a receiver-operating curve (ROC) analysis based on mortality. We further defined mild and moderate categories by the standard deviation distance between normal and severely dilated and found the categories RV dilation by RV/LV volume ratio to be “mild” (1.27–1.69), “moderate” (1.70–2.29) and “severe” (≥2.30). There were significant differences in RVEDV and RV ejection fraction between “mild”, “moderate” and “severe” groups (p < 0.001). The “severe” category had a significantly higher mortality when compared to the “non-severe” categories (p < 0.001) while there was no difference among the “non-severe” dilated groups. We have shown that severe RV dilation partition can be defined using mortality with RV/LV volume ratio, which offers an outcome based grading of the “severe” category of RV dilation.
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spelling pubmed-59408932018-05-14 Using all-cause mortality to define severe RV dilation with RV/LV volume ratio Altmayer, Stephan P. L. Han, Q. Joyce Addetia, Karima Patel, Amit R. Forfia, Paul R. Han, Yuchi Sci Rep Article Right ventricular (RV) end-diastolic volume (EDV) to left ventricular (LV) EDV ratio using cardiovascular magnetic resonance imaging (CMR) is an important parameter for RV size evaluation in additional to indexed EDV. We explore the severity partition for RV dilation using mortality in a population of 62 patients with pulmonary hypertension (PH). Cine short-axis images were acquired with a 1.5 T MR scanner using a steady-state free precession sequence. The optimal cutoff to classify severe RV dilation was determined by a receiver-operating curve (ROC) analysis based on mortality. We further defined mild and moderate categories by the standard deviation distance between normal and severely dilated and found the categories RV dilation by RV/LV volume ratio to be “mild” (1.27–1.69), “moderate” (1.70–2.29) and “severe” (≥2.30). There were significant differences in RVEDV and RV ejection fraction between “mild”, “moderate” and “severe” groups (p < 0.001). The “severe” category had a significantly higher mortality when compared to the “non-severe” categories (p < 0.001) while there was no difference among the “non-severe” dilated groups. We have shown that severe RV dilation partition can be defined using mortality with RV/LV volume ratio, which offers an outcome based grading of the “severe” category of RV dilation. Nature Publishing Group UK 2018-05-08 /pmc/articles/PMC5940893/ /pubmed/29739967 http://dx.doi.org/10.1038/s41598-018-25259-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Altmayer, Stephan P. L.
Han, Q. Joyce
Addetia, Karima
Patel, Amit R.
Forfia, Paul R.
Han, Yuchi
Using all-cause mortality to define severe RV dilation with RV/LV volume ratio
title Using all-cause mortality to define severe RV dilation with RV/LV volume ratio
title_full Using all-cause mortality to define severe RV dilation with RV/LV volume ratio
title_fullStr Using all-cause mortality to define severe RV dilation with RV/LV volume ratio
title_full_unstemmed Using all-cause mortality to define severe RV dilation with RV/LV volume ratio
title_short Using all-cause mortality to define severe RV dilation with RV/LV volume ratio
title_sort using all-cause mortality to define severe rv dilation with rv/lv volume ratio
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940893/
https://www.ncbi.nlm.nih.gov/pubmed/29739967
http://dx.doi.org/10.1038/s41598-018-25259-1
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