Cargando…
Dual actions of Psalmotoxin at ASIC1a and ASIC2a heteromeric channels (ASIC1a/2a)
Acid-Sensing Ion Channels (ASICs) are gated by extracellular protons and play important roles in physiological and pathological states, such as pain and stroke. ASIC1a and ASIC2a, two of the most highly expressed subunits in the brain, form functional homo- and hetero-meric (ASIC1a/2a) channels. The...
Autores principales: | Liu, Yi, Hagan, Rebecca, Schoellerman, Jeffrey |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940917/ https://www.ncbi.nlm.nih.gov/pubmed/29739981 http://dx.doi.org/10.1038/s41598-018-25386-9 |
Ejemplares similares
-
Interaction of Acid-sensing Ion Channel (ASIC) 1 with the Tarantula Toxin Psalmotoxin 1 is State Dependent
por: Chen, Xuanmao, et al.
Publicado: (2006) -
Acid-Sensing Ion Channel 2a (ASIC2a) Promotes Surface Trafficking of ASIC2b via Heteromeric Assembly
por: Kweon, Hae-Jin, et al.
Publicado: (2016) -
Endogenous Neuropeptide Nocistatin Is a Direct Agonist of Acid-Sensing Ion Channels (ASIC1, ASIC2 and ASIC3)
por: Osmakov, Dmitry I., et al.
Publicado: (2019) -
The Tarantula Toxin Psalmotoxin 1 Inhibits Acid-sensing Ion Channel (ASIC) 1a by Increasing Its Apparent H(+) Affinity
por: Chen, Xuanmao, et al.
Publicado: (2005) -
Simultaneous Disruption of Mouse ASIC1a, ASIC2 and ASIC3 Genes Enhances Cutaneous Mechanosensitivity
por: Kang, Sinyoung, et al.
Publicado: (2012)