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A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review

BACKGROUND: Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a neoplasm composed of both exocrine and endocrine carcinomas, each comprising at least 30% of the tumor. MANEC can occur in various organs of the gastrointestinal tract, including the esophagus, stomach, and colon. We herein prov...

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Autores principales: Kawazoe, Tetsuro, Saeki, Hiroshi, Edahiro, Keitaro, Korehisa, Shotaro, Taniguchi, Daisuke, Kudou, Kensuke, Nakanishi, Ryota, Kubo, Nobuhide, Ando, Koji, Nakashima, Yuichiro, Oki, Eiji, Fujiwara, Minako, Oda, Yoshinao, Maehara, Yoshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940966/
https://www.ncbi.nlm.nih.gov/pubmed/29740725
http://dx.doi.org/10.1186/s40792-018-0454-z
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author Kawazoe, Tetsuro
Saeki, Hiroshi
Edahiro, Keitaro
Korehisa, Shotaro
Taniguchi, Daisuke
Kudou, Kensuke
Nakanishi, Ryota
Kubo, Nobuhide
Ando, Koji
Nakashima, Yuichiro
Oki, Eiji
Fujiwara, Minako
Oda, Yoshinao
Maehara, Yoshihiko
author_facet Kawazoe, Tetsuro
Saeki, Hiroshi
Edahiro, Keitaro
Korehisa, Shotaro
Taniguchi, Daisuke
Kudou, Kensuke
Nakanishi, Ryota
Kubo, Nobuhide
Ando, Koji
Nakashima, Yuichiro
Oki, Eiji
Fujiwara, Minako
Oda, Yoshinao
Maehara, Yoshihiko
author_sort Kawazoe, Tetsuro
collection PubMed
description BACKGROUND: Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a neoplasm composed of both exocrine and endocrine carcinomas, each comprising at least 30% of the tumor. MANEC can occur in various organs of the gastrointestinal tract, including the esophagus, stomach, and colon. We herein provide the first case report of surgically resected MANEC arising in Barrett’s esophagus (BE). CASE PRESENTATION: A 70-year-old man presenting with abdominal pain was referred to our hospital. Upper endoscopy showed a type 0-IIa + IIc elevated lesion adjacent to BE. According to a biopsy specimen, the elevated lesion was diagnosed as adenocarcinoma with neuroendocrine differentiation. No lymphatic or distant metastasis was detected in the preoperative examination. Laparoscopic distal esophagectomy and proximal gastrectomy were performed, and a diagnosis of MANEC in BE was determined according to the surgically resected specimen. CONCLUSIONS: A very rare case of MANEC in BE was detected. BE can be the origin of esophageal MANEC as well as adenocarcinoma. Due to the small number of esophageal or esophagogastric MANEC cases reported, further accumulation of such cases is necessary to recommend an optimal management strategy for esophageal or esophagogastric MANEC.
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spelling pubmed-59409662018-05-14 A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review Kawazoe, Tetsuro Saeki, Hiroshi Edahiro, Keitaro Korehisa, Shotaro Taniguchi, Daisuke Kudou, Kensuke Nakanishi, Ryota Kubo, Nobuhide Ando, Koji Nakashima, Yuichiro Oki, Eiji Fujiwara, Minako Oda, Yoshinao Maehara, Yoshihiko Surg Case Rep Case Report BACKGROUND: Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a neoplasm composed of both exocrine and endocrine carcinomas, each comprising at least 30% of the tumor. MANEC can occur in various organs of the gastrointestinal tract, including the esophagus, stomach, and colon. We herein provide the first case report of surgically resected MANEC arising in Barrett’s esophagus (BE). CASE PRESENTATION: A 70-year-old man presenting with abdominal pain was referred to our hospital. Upper endoscopy showed a type 0-IIa + IIc elevated lesion adjacent to BE. According to a biopsy specimen, the elevated lesion was diagnosed as adenocarcinoma with neuroendocrine differentiation. No lymphatic or distant metastasis was detected in the preoperative examination. Laparoscopic distal esophagectomy and proximal gastrectomy were performed, and a diagnosis of MANEC in BE was determined according to the surgically resected specimen. CONCLUSIONS: A very rare case of MANEC in BE was detected. BE can be the origin of esophageal MANEC as well as adenocarcinoma. Due to the small number of esophageal or esophagogastric MANEC cases reported, further accumulation of such cases is necessary to recommend an optimal management strategy for esophageal or esophagogastric MANEC. Springer Berlin Heidelberg 2018-05-08 /pmc/articles/PMC5940966/ /pubmed/29740725 http://dx.doi.org/10.1186/s40792-018-0454-z Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Kawazoe, Tetsuro
Saeki, Hiroshi
Edahiro, Keitaro
Korehisa, Shotaro
Taniguchi, Daisuke
Kudou, Kensuke
Nakanishi, Ryota
Kubo, Nobuhide
Ando, Koji
Nakashima, Yuichiro
Oki, Eiji
Fujiwara, Minako
Oda, Yoshinao
Maehara, Yoshihiko
A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review
title A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review
title_full A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review
title_fullStr A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review
title_full_unstemmed A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review
title_short A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review
title_sort case of mixed adenoneuroendocrine carcinoma (manec) arising in barrett’s esophagus: literature and review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940966/
https://www.ncbi.nlm.nih.gov/pubmed/29740725
http://dx.doi.org/10.1186/s40792-018-0454-z
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