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A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review
BACKGROUND: Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a neoplasm composed of both exocrine and endocrine carcinomas, each comprising at least 30% of the tumor. MANEC can occur in various organs of the gastrointestinal tract, including the esophagus, stomach, and colon. We herein prov...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940966/ https://www.ncbi.nlm.nih.gov/pubmed/29740725 http://dx.doi.org/10.1186/s40792-018-0454-z |
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author | Kawazoe, Tetsuro Saeki, Hiroshi Edahiro, Keitaro Korehisa, Shotaro Taniguchi, Daisuke Kudou, Kensuke Nakanishi, Ryota Kubo, Nobuhide Ando, Koji Nakashima, Yuichiro Oki, Eiji Fujiwara, Minako Oda, Yoshinao Maehara, Yoshihiko |
author_facet | Kawazoe, Tetsuro Saeki, Hiroshi Edahiro, Keitaro Korehisa, Shotaro Taniguchi, Daisuke Kudou, Kensuke Nakanishi, Ryota Kubo, Nobuhide Ando, Koji Nakashima, Yuichiro Oki, Eiji Fujiwara, Minako Oda, Yoshinao Maehara, Yoshihiko |
author_sort | Kawazoe, Tetsuro |
collection | PubMed |
description | BACKGROUND: Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a neoplasm composed of both exocrine and endocrine carcinomas, each comprising at least 30% of the tumor. MANEC can occur in various organs of the gastrointestinal tract, including the esophagus, stomach, and colon. We herein provide the first case report of surgically resected MANEC arising in Barrett’s esophagus (BE). CASE PRESENTATION: A 70-year-old man presenting with abdominal pain was referred to our hospital. Upper endoscopy showed a type 0-IIa + IIc elevated lesion adjacent to BE. According to a biopsy specimen, the elevated lesion was diagnosed as adenocarcinoma with neuroendocrine differentiation. No lymphatic or distant metastasis was detected in the preoperative examination. Laparoscopic distal esophagectomy and proximal gastrectomy were performed, and a diagnosis of MANEC in BE was determined according to the surgically resected specimen. CONCLUSIONS: A very rare case of MANEC in BE was detected. BE can be the origin of esophageal MANEC as well as adenocarcinoma. Due to the small number of esophageal or esophagogastric MANEC cases reported, further accumulation of such cases is necessary to recommend an optimal management strategy for esophageal or esophagogastric MANEC. |
format | Online Article Text |
id | pubmed-5940966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-59409662018-05-14 A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review Kawazoe, Tetsuro Saeki, Hiroshi Edahiro, Keitaro Korehisa, Shotaro Taniguchi, Daisuke Kudou, Kensuke Nakanishi, Ryota Kubo, Nobuhide Ando, Koji Nakashima, Yuichiro Oki, Eiji Fujiwara, Minako Oda, Yoshinao Maehara, Yoshihiko Surg Case Rep Case Report BACKGROUND: Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a neoplasm composed of both exocrine and endocrine carcinomas, each comprising at least 30% of the tumor. MANEC can occur in various organs of the gastrointestinal tract, including the esophagus, stomach, and colon. We herein provide the first case report of surgically resected MANEC arising in Barrett’s esophagus (BE). CASE PRESENTATION: A 70-year-old man presenting with abdominal pain was referred to our hospital. Upper endoscopy showed a type 0-IIa + IIc elevated lesion adjacent to BE. According to a biopsy specimen, the elevated lesion was diagnosed as adenocarcinoma with neuroendocrine differentiation. No lymphatic or distant metastasis was detected in the preoperative examination. Laparoscopic distal esophagectomy and proximal gastrectomy were performed, and a diagnosis of MANEC in BE was determined according to the surgically resected specimen. CONCLUSIONS: A very rare case of MANEC in BE was detected. BE can be the origin of esophageal MANEC as well as adenocarcinoma. Due to the small number of esophageal or esophagogastric MANEC cases reported, further accumulation of such cases is necessary to recommend an optimal management strategy for esophageal or esophagogastric MANEC. Springer Berlin Heidelberg 2018-05-08 /pmc/articles/PMC5940966/ /pubmed/29740725 http://dx.doi.org/10.1186/s40792-018-0454-z Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Case Report Kawazoe, Tetsuro Saeki, Hiroshi Edahiro, Keitaro Korehisa, Shotaro Taniguchi, Daisuke Kudou, Kensuke Nakanishi, Ryota Kubo, Nobuhide Ando, Koji Nakashima, Yuichiro Oki, Eiji Fujiwara, Minako Oda, Yoshinao Maehara, Yoshihiko A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review |
title | A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review |
title_full | A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review |
title_fullStr | A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review |
title_full_unstemmed | A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review |
title_short | A case of mixed adenoneuroendocrine carcinoma (MANEC) arising in Barrett’s esophagus: literature and review |
title_sort | case of mixed adenoneuroendocrine carcinoma (manec) arising in barrett’s esophagus: literature and review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940966/ https://www.ncbi.nlm.nih.gov/pubmed/29740725 http://dx.doi.org/10.1186/s40792-018-0454-z |
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