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Loss of Ethanolamine Utilization in Enterococcus faecalis Increases Gastrointestinal Tract Colonization
Enterococcus faecalis is paradoxically a dangerous nosocomial pathogen and a normal constituent of the human gut microbiome, an environment rich in ethanolamine. E. faecalis carries the eut (ethanolamine utilization) genes, which enable the catabolism of ethanolamine (EA) as a valuable source of car...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941071/ https://www.ncbi.nlm.nih.gov/pubmed/29739905 http://dx.doi.org/10.1128/mBio.00790-18 |
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author | Kaval, Karan Gautam Singh, Kavindra V. Cruz, Melissa R. DebRoy, Sruti Winkler, Wade C. Murray, Barbara E. Garsin, Danielle A. |
author_facet | Kaval, Karan Gautam Singh, Kavindra V. Cruz, Melissa R. DebRoy, Sruti Winkler, Wade C. Murray, Barbara E. Garsin, Danielle A. |
author_sort | Kaval, Karan Gautam |
collection | PubMed |
description | Enterococcus faecalis is paradoxically a dangerous nosocomial pathogen and a normal constituent of the human gut microbiome, an environment rich in ethanolamine. E. faecalis carries the eut (ethanolamine utilization) genes, which enable the catabolism of ethanolamine (EA) as a valuable source of carbon and/or nitrogen. EA catabolism was previously shown to contribute to the colonization and growth of enteric pathogens, such as Salmonella enterica serovar Typhimurium and enterohemorrhagic Escherichia coli (EHEC), in the gut environment. We tested the ability of eut mutants of E. faecalis to colonize the gut using a murine model of gastrointestinal (GI) tract competition and report the surprising observation that these mutants outcompete the wild-type strain. |
format | Online Article Text |
id | pubmed-5941071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-59410712018-05-15 Loss of Ethanolamine Utilization in Enterococcus faecalis Increases Gastrointestinal Tract Colonization Kaval, Karan Gautam Singh, Kavindra V. Cruz, Melissa R. DebRoy, Sruti Winkler, Wade C. Murray, Barbara E. Garsin, Danielle A. mBio Observation Enterococcus faecalis is paradoxically a dangerous nosocomial pathogen and a normal constituent of the human gut microbiome, an environment rich in ethanolamine. E. faecalis carries the eut (ethanolamine utilization) genes, which enable the catabolism of ethanolamine (EA) as a valuable source of carbon and/or nitrogen. EA catabolism was previously shown to contribute to the colonization and growth of enteric pathogens, such as Salmonella enterica serovar Typhimurium and enterohemorrhagic Escherichia coli (EHEC), in the gut environment. We tested the ability of eut mutants of E. faecalis to colonize the gut using a murine model of gastrointestinal (GI) tract competition and report the surprising observation that these mutants outcompete the wild-type strain. American Society for Microbiology 2018-05-08 /pmc/articles/PMC5941071/ /pubmed/29739905 http://dx.doi.org/10.1128/mBio.00790-18 Text en Copyright © 2018 Kaval et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Observation Kaval, Karan Gautam Singh, Kavindra V. Cruz, Melissa R. DebRoy, Sruti Winkler, Wade C. Murray, Barbara E. Garsin, Danielle A. Loss of Ethanolamine Utilization in Enterococcus faecalis Increases Gastrointestinal Tract Colonization |
title | Loss of Ethanolamine Utilization in Enterococcus faecalis Increases Gastrointestinal Tract Colonization |
title_full | Loss of Ethanolamine Utilization in Enterococcus faecalis Increases Gastrointestinal Tract Colonization |
title_fullStr | Loss of Ethanolamine Utilization in Enterococcus faecalis Increases Gastrointestinal Tract Colonization |
title_full_unstemmed | Loss of Ethanolamine Utilization in Enterococcus faecalis Increases Gastrointestinal Tract Colonization |
title_short | Loss of Ethanolamine Utilization in Enterococcus faecalis Increases Gastrointestinal Tract Colonization |
title_sort | loss of ethanolamine utilization in enterococcus faecalis increases gastrointestinal tract colonization |
topic | Observation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941071/ https://www.ncbi.nlm.nih.gov/pubmed/29739905 http://dx.doi.org/10.1128/mBio.00790-18 |
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