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Repurposing Cytarabine for Treating Primary Effusion Lymphoma by Targeting Kaposi’s Sarcoma-Associated Herpesvirus Latent and Lytic Replications

Oncogenic Kaposi’s sarcoma-associated herpesvirus (KSHV) is etiologically linked to primary effusion lymphoma (PEL), an aggressive and nontreatable malignancy commonly found in AIDS patients. In this study, we performed a high-throughput screening of 3,731 characterized compounds and identified cyta...

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Detalles Bibliográficos
Autores principales: Gruffaz, Marion, Zhou, Shenghua, Vasan, Karthik, Rushing, Teresa, Michael, Qing Liu, Lu, Chu, Jung, Jae U., Gao, Shou-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941074/
https://www.ncbi.nlm.nih.gov/pubmed/29739902
http://dx.doi.org/10.1128/mBio.00756-18