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Shared dynamics of LeuT superfamily members and allosteric differentiation by structural irregularities and multimerization

The LeuT-fold superfamily includes secondary active transporters from different functional families, which share a common tertiary structure, despite having a remarkably low sequence similarity. By identifying the common structural and dynamical features upon principal component analysis of a compre...

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Detalles Bibliográficos
Autores principales: Ponzoni, Luca, Zhang, She, Cheng, Mary Hongying, Bahar, Ivet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941172/
https://www.ncbi.nlm.nih.gov/pubmed/29735731
http://dx.doi.org/10.1098/rstb.2017.0177