Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics

Gram-negative bacterial lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) mediated pro-inflammatory signaling plays a key role in immunoprotection against infectious challenges and boosts adaptive immunity, whereas the activation of the cytosolic LPS receptor caspase-4/11 leads to cell de...

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Detalles Bibliográficos
Autores principales: Adanitsch, Florian, Shi, Jianjin, Shao, Feng, Beyaert, Rudi, Heine, Holger, Zamyatina, Alla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941199/
https://www.ncbi.nlm.nih.gov/pubmed/29780528
http://dx.doi.org/10.1039/c7sc05323a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941199/
https://www.ncbi.nlm.nih.gov/pubmed/29780528
http://dx.doi.org/10.1039/c7sc05323a

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