ATOH1/RFX1/RFX3 transcription factors facilitate the differentiation and characterisation of inner ear hair cell-like cells from patient-specific induced pluripotent stem cells harbouring A8344G mutation of mitochondrial DNA

Degeneration or loss of inner ear hair cells (HCs) is irreversible and results in sensorineural hearing loss (SHL). Human-induced pluripotent stem cells (hiPSCs) have been employed in disease modelling and cell therapy. Here, we propose a transcription factor (TF)-driven approach using ATOH1 and reg...

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Detalles Bibliográficos
Autores principales: Chen, Yen-Chun, Tsai, Chia-Ling, Wei, Yau-Huei, Wu, Yu-Ting, Hsu, Wei-Ting, Lin, Hung-Ching, Hsu, Yi-Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941227/
https://www.ncbi.nlm.nih.gov/pubmed/29740017
http://dx.doi.org/10.1038/s41419-018-0488-y

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