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Effects of yeast cell wall on growth performance, immune responses and intestinal short chain fatty acid concentrations of broilers in an experimental necrotic enteritis model
Subclinical necrotic enteritis (NE) causes devastating economic losses in the broiler chicken industry, especially in birds raised free of in-feed antibiotics. Prebiotics are potential alternatives to in-feed antibiotics. Yeast cell wall extract (YCW) derived from Saccharomyces cerevisiae is a prebi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941278/ https://www.ncbi.nlm.nih.gov/pubmed/29767160 http://dx.doi.org/10.1016/j.aninu.2017.08.002 |
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author | Xue, Guang-Da Wu, Shu-Biao Choct, Mingan Swick, Robert A. |
author_facet | Xue, Guang-Da Wu, Shu-Biao Choct, Mingan Swick, Robert A. |
author_sort | Xue, Guang-Da |
collection | PubMed |
description | Subclinical necrotic enteritis (NE) causes devastating economic losses in the broiler chicken industry, especially in birds raised free of in-feed antibiotics. Prebiotics are potential alternatives to in-feed antibiotics. Yeast cell wall extract (YCW) derived from Saccharomyces cerevisiae is a prebiotic with known immune modulating effects. This study examined the effects of YCW and antibiotics (AB) during subclinical NE on broiler growth performance, intestinal lesions, humoral immune response and gut microflora metabolites. The study employed a 2 × 3 factorial arrangement of treatments. Factors were: NE challenge (yes or no) and feed additive (control, AB, or YCW). Each treatment was replicated in 8 floor pens with 15 birds per pen. Challenged birds had higher feed conversion ratio (FCR) than unchallenged birds on d 35 (P < 0.05). Dietary inclusion of AB decreased FCR regardless of challenge (P < 0.05) on d 24 and 35. Inclusion of YCW reduced serum interleukin-1 (IL-1) concentration in NE challenged birds (P < 0.01) and increased immunoglobulin (Ig) G (P < 0.05) and Ig M (P < 0.05) levels compared to other dietary treatments regardless of challenge. Yeast cell wall extract increased formic acid concentration in cecal contents during challenge and increased butyric acid concentration in unchallenged birds on d 16. This study indicates YCW suppressed inflammatory response, promoted generation of immunoglobulin and increased short chain fatty acid production suggesting potential benefits to bird health. |
format | Online Article Text |
id | pubmed-5941278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-59412782018-05-14 Effects of yeast cell wall on growth performance, immune responses and intestinal short chain fatty acid concentrations of broilers in an experimental necrotic enteritis model Xue, Guang-Da Wu, Shu-Biao Choct, Mingan Swick, Robert A. Anim Nutr Poultry Nutrition Subclinical necrotic enteritis (NE) causes devastating economic losses in the broiler chicken industry, especially in birds raised free of in-feed antibiotics. Prebiotics are potential alternatives to in-feed antibiotics. Yeast cell wall extract (YCW) derived from Saccharomyces cerevisiae is a prebiotic with known immune modulating effects. This study examined the effects of YCW and antibiotics (AB) during subclinical NE on broiler growth performance, intestinal lesions, humoral immune response and gut microflora metabolites. The study employed a 2 × 3 factorial arrangement of treatments. Factors were: NE challenge (yes or no) and feed additive (control, AB, or YCW). Each treatment was replicated in 8 floor pens with 15 birds per pen. Challenged birds had higher feed conversion ratio (FCR) than unchallenged birds on d 35 (P < 0.05). Dietary inclusion of AB decreased FCR regardless of challenge (P < 0.05) on d 24 and 35. Inclusion of YCW reduced serum interleukin-1 (IL-1) concentration in NE challenged birds (P < 0.01) and increased immunoglobulin (Ig) G (P < 0.05) and Ig M (P < 0.05) levels compared to other dietary treatments regardless of challenge. Yeast cell wall extract increased formic acid concentration in cecal contents during challenge and increased butyric acid concentration in unchallenged birds on d 16. This study indicates YCW suppressed inflammatory response, promoted generation of immunoglobulin and increased short chain fatty acid production suggesting potential benefits to bird health. KeAi Publishing 2017-12 2017-08-18 /pmc/articles/PMC5941278/ /pubmed/29767160 http://dx.doi.org/10.1016/j.aninu.2017.08.002 Text en © 2017, Chinese Association of Animal Science and Veterinary Medicine. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Poultry Nutrition Xue, Guang-Da Wu, Shu-Biao Choct, Mingan Swick, Robert A. Effects of yeast cell wall on growth performance, immune responses and intestinal short chain fatty acid concentrations of broilers in an experimental necrotic enteritis model |
title | Effects of yeast cell wall on growth performance, immune responses and intestinal short chain fatty acid concentrations of broilers in an experimental necrotic enteritis model |
title_full | Effects of yeast cell wall on growth performance, immune responses and intestinal short chain fatty acid concentrations of broilers in an experimental necrotic enteritis model |
title_fullStr | Effects of yeast cell wall on growth performance, immune responses and intestinal short chain fatty acid concentrations of broilers in an experimental necrotic enteritis model |
title_full_unstemmed | Effects of yeast cell wall on growth performance, immune responses and intestinal short chain fatty acid concentrations of broilers in an experimental necrotic enteritis model |
title_short | Effects of yeast cell wall on growth performance, immune responses and intestinal short chain fatty acid concentrations of broilers in an experimental necrotic enteritis model |
title_sort | effects of yeast cell wall on growth performance, immune responses and intestinal short chain fatty acid concentrations of broilers in an experimental necrotic enteritis model |
topic | Poultry Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941278/ https://www.ncbi.nlm.nih.gov/pubmed/29767160 http://dx.doi.org/10.1016/j.aninu.2017.08.002 |
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